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Commonly used estimates of the genetic contribution to disease are subject to the same fallacies as bad luck estimates

The scientific debate following the initial formulation of the “bad luck” hypothesis in cancer development highlighted how measures based on analysis of variance are inappropriately used for risk communication. The notion of “explained” variance is not only used to quantify randomness, but also to quantify genetic and environmental contribution to disease in heritability coefficients. New publicat

https://www.lupop.lu.se/article/commonly-used-estimates-genetic-contribution-disease-are-subject-same-fallacies-bad-luck-estimates - 2025-10-15

Whole-genome sequencing of triple-negative breast cancers in a population-based clinical study

Whole-genome sequencing (WGS) brings comprehensive insights to cancer genome interpretation. To explore the clinical value of WGS, we sequenced 254 triple-negative breast cancers (TNBCs) for which associated treatment and outcome data were collected between 2010 and 2015 via the population-based Sweden Cancerome Analysis Network–Breast (SCAN-B) project (ClinicalTrials.gov ID:NCT02306096). New publ

https://www.lupop.lu.se/article/whole-genome-sequencing-triple-negative-breast-cancers-population-based-clinical-study - 2025-10-15

Population-Based Observational Studies in Oncology: Proceed With Caution

A principle goal of research in Oncology is to determine the optimal treatment for our patients. This often takes the form of comparing 2 existing therapies to one another to determine which is superior, or to introduce a new therapy and determine if it is superior or noninferior to the existing standard of care. New publication in Seminars in Radiation Oncology

https://www.lupop.lu.se/article/population-based-observational-studies-oncology-proceed-caution - 2025-10-15

Validation of diagnosis codes to identify side of colon in an electronic health record registry

ICD codes are a highly reliable indicator of tumor location when the specific location code is entered in the EHR. However, non-specific side of colon ICD codes are present for a sizable minority of patients, and structured data alone may not be adequate to support testing of some research hypotheses. New publication in BMC Medical Research Methodology

https://www.lupop.lu.se/article/validation-diagnosis-codes-identify-side-colon-electronic-health-record-registry - 2025-10-15

Key concepts and principles for design and critical interpretation of Nordic register-based studies

This two-week course is divided into two separate course weeks. The course will be arranged as a retreat somewhere in Sweden. Travel costs and accommodation will be covered in relation to the educational activities. The target group is doctoral students (and those who have recently completed their doctoral education) involved in register-based research within their research training. Eligible appl

https://www.lupop.lu.se/article/key-concepts-and-principles-design-and-critical-interpretation-nordic-register-based-studies-0 - 2025-10-15

A critical reflection on the grading of the certainty of evidence in umbrella reviews

In conclusion, umbrella reviews provide a comprehensive overview of a specific research topic and are very helpful tools to evaluate the certainty of evidence. These systematic overviews are helpful for the translation of research findings into recommendations, and also for identifying new research directions. New publication in European Journal of Epidemiology

https://www.lupop.lu.se/article/critical-reflection-grading-certainty-evidence-umbrella-reviews - 2025-10-15

Chronic pain: a review of its epidemiology and associated factors in population-based studies

Chronic pain is a common, complex, and distressing problem that has a profound impact on individuals and society. It frequently presents as a result of a disease or an injury; however, it is not merely an accompanying symptom, but rather a separate condition in its own right, with its own medical definition and taxonomy. New publication in British Journal of Anaesthesia

https://www.lupop.lu.se/article/chronic-pain-review-its-epidemiology-and-associated-factors-population-based-studies - 2025-10-15

Doing more of less: what registry data tell us about death in PICU

The development of paediatric critical care registries, a term we take to include national audits and research databases, has been instrumental in helping us understand the state of children’s critical care and thereby provide a platform for future improvement. Comprehensive datasets enable monitoring of activity and outcomes for audit, safety and service planning. New publication in Intensive Car

https://www.lupop.lu.se/article/doing-more-less-what-registry-data-tell-us-about-death-picu - 2025-10-15

Twin Registries Moving Forward and Meeting the Future: A Review

Twin registries have developed as a valuable resource for the study of many aspects of disease and society over the years in many different countries. A number of these registries include large numbers of twins with data collected at varying information levels for twin cohorts over the past several decades. New publication in Cambridge Core

https://www.lupop.lu.se/article/twin-registries-moving-forward-and-meeting-future-review - 2025-10-15

Ny utlysning från Vetenskapsrådet

Detta bidrag syftar till att stödja internationella samarbeten inom det europeiska programmet CHIST-ERA, som stödjer forskning inom informations- och kommunikationsteknologi (IKT). Sverige är via Vetenskapsrådet ett av de 24 länder som deltar i CHIST-ERA-utlysningen där forskning av högsta vetenskapliga kvalitet i internationell konkurrens premieras. Vetenskapsrådet deltar i utlysningen inom ämne

https://www.lupop.lu.se/article/ny-utlysning-fran-vetenskapsradet - 2025-10-15

Nya utlysningar från Vetenskapsrådet

Följande utlysningar från Vetenskapsrådet är nu öppna. Bidrag för aktiviteter inom MINT-ämnen vid nationella forskningsinfrastrukturer (Söks av organisation)Tage Erlanders gästprofessur (Söks av organisation)Bidrag till forskningsmiljö inom klinisk behandlingsforskningKonsolideringsbidrag (Skissansökan)Internationell postdokKerstin Hesselgrens gästprofessur (Söks av organisation)Olof Palmes gästpr

https://www.lupop.lu.se/article/nya-utlysningar-fran-vetenskapsradet-0 - 2025-10-15

Nya utlysningar från VR

Följande utlysningar från Vetenskapsrådet är nu öppna Projektbidrag inom humaniora och samhällsvetenskap  Projektbidrag inom medicin och hälsaProjektbidrag för digitalisering och tillgängliggörande av kulturarvssamlingarProjektbidrag för utveckling av metoder för ersättning, begränsning och förfining av djurförsök (3R)Tidskriftsbidrag inom humaniora och samhällsvetenskap (Söks av organisation)Bidr

https://www.lupop.lu.se/article/nya-utlysningar-fran-vr - 2025-10-15

National poisoning registers and toxicovigilance in different countries as models for Germany

As of 2019, Germany has still not been able to provide a national poisoning register and toxicovigilance for sufficient and reliable information on human exposure for the purpose of identification and assessment of toxic risk to the public. In particular, the USA acts as a special model, but France, the Netherlands, Switzerland, and Sweden also have efficient poisoning registers and toxicovigilanc

https://www.lupop.lu.se/article/national-poisoning-registers-and-toxicovigilance-different-countries-models-germany - 2025-10-15

Prediction of Lymph Node Metastasis in Breast Cancer by Gene Expression and Clinicopathological Models: Development and Validation within a Population-Based Cohort

More than 70% of patients with breast cancer present with node-negative disease, yet all undergo surgical axillary staging. We aimed to define predictors of nodal metastasis using clinicopathological characteristics (CLINICAL), gene expression data (GEX), and mixed features (MIXED) and to identify patients at low risk of metastasis who might be spared sentinel lymph node biopsy (SLNB). New publica

https://www.lupop.lu.se/article/prediction-lymph-node-metastasis-breast-cancer-gene-expression-and-clinicopathological-models - 2025-10-15

Developing and Launching a Research Participant Registry

A major challenge in clinical research today is the difficulty that studies have in meeting recruitment goals. Up to 48% of studies do not meet accrual goals within the specified timeframe, significantly delaying the progress of projects and the dissemination of findings. This pervasive problem is a recruitment crisis. We developed a representative, ethnically and racially diverse research partici

https://www.lupop.lu.se/article/developing-and-launching-research-participant-registry - 2025-10-15