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Synthesis and Biological Studies of O3-Aryl Galactosides as Galectin Inhibitors

β-Galactose derivatives have recently been reported to selectively inhibit galectin-3, and a library of O3-arylated galactosides with varying substitution patterns was designed to study such inhibitions further. The O3-arylated galactosides were synthesized using diaryliodonium salts under mild and transition metal free conditions, providing the target products in moderate to good yields. An O3-tr

Fixing Sample Biases in Experimental Data Using Agent-Based Modelling

We present how agent-based models can be used to correct for biases in a sample. The approach is generally useful for behavioural experiments where participants interact over time. The model we developed copied mechanics of a behavioural experiment conducted earlier, and agents in the model faced the same strategic choices as human participants did. We used the data from the experiment to calibrat

Use of fuzzy cognitive maps to develop policy strategies for the optimization of municipal waste management: A case study of the land of fires (Italy)

This paper applies an analytical method for developing policy strategies to optimize municipal waste management systems (MWMSs) to the case of the Land of Fires (LoF). The LoF is an area of Italy’s Campania region that is characterized by a legacy of authoritarian environmental governance and the improper dumping and burning of waste. In this paper, we employ the fuzzy cognitive maps (FCM) method,

Contaminant, Commodity and Fuel: A Multi‐sited Study of Waste's roles in Urban Transformations from Italy to Austria

This article traces the flow of municipal solid waste from southern Italy through a waste‐to‐energy facility and district heating system in Austria, examining the roles that waste's transformation from contaminant to commodity to fuel plays in interconnected, distributed, and contested urbanization processes. It contends that, while metabolic circulation hides socioecological costs in one place to

Conceptualising the foreign policies of EU Member States

This introduction presents an overview of the key concepts discussed in the subsequent chapters of this book. The book describes the European Union's (EU) Member States have embarked on a unique project in seeking to create a collective foreign, security and defence policy. This collective foreign policy endeavour has been pursued whilst national foreign policies themselves have evolved. EU foreig

Conclusion

This conclusion presents some closing thoughts on the concepts covered in the preceding chapters of this book. The book empirically and comparatively, indicates the extent to which there is continuity or change in the foreign policy composition of key European Union (EU) Member States, as found across the 'strong-weak competence spectrum', and on this basis explore the extent to which the resultin

Historically Based Room Acoustic Analysis and Auralization of a Church in the 1470s

Worship space acoustics have been established as an important part of a nation’s cultural heritage and area of acoustic research, but more research is needed regarding the region of northern Europe. This paper describes the historical acoustics of an important abbey church in Sweden in the 1470s. A digital historical reconstruction is developed. Liturgical material specific to this location is rec

Rättegången mot Quisling - en norsk Nürnbergprocess

Rättsfallspodd från Juridiska fakulteten.Under andra världskriget är Vidkun Quisling norsk regeringschef i den tyska ockupationen av Norge. Efter kriget ställs Quisling inför rätta och åtalas för landsförräderi. Rättegången mot Quisling är en berättelse om nedmonteringen av den norska rättsstaten under ockupationen, men det är också en historia om hur norrmännen gjorde motstånd och försvarade rätt

The pupil-size artefact (PSA) across time, viewing direction, and different eye trackers

The pupil size artefact (PSA) is the gaze deviation reported by an eye tracker during pupil size changes if the eye does not rotate. In the present study, we ask three questions: 1) how stable is the PSA over time, 2) does the PSA depend on properties of the eye tracker set up, and 3) does the PSA depend on the participants' viewing direction? We found that the PSA is very stable over time for per

Mathematical modelling of post-filter ionized calcium during citrate anticoagulated continuous renal replacement therapy

Background/Aims Post-filter ionized calcium (iCa) measured on a blood gas analyzer (BGA) during regional citrate anticoagulated continuous renal replacement therapy (CRRT) are needed to control the regime. This increases the workload and requires attention including interpretation of blood analyses. Two algorithms were developed to calculate the post-filter iCa instead. The first algorithm used me

Antibiotic Prescription Rates After eVisits Versus Office Visits in Primary Care : Observational Study

BACKGROUND: Direct-to-consumer telemedicine is an increasingly used modality to access primary care. Previous research on assessment using synchronous virtual visits showed mixed results regarding antibiotic prescription rates, and research on assessment using asynchronous chat-based eVisits is lacking.OBJECTIVE: The goal of the research was to investigate if eVisit management of sore throat, othe

Development and Validation of a Modified Full Age Spectrum Creatinine-Based Equation to Estimate Glomerular Filtration Rate : A Cross-sectional Analysis of Pooled Data

BACKGROUND: The Chronic Kidney Disease in Children Study (CKiD) equation for children and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation for adults are recommended serum creatinine (SCr)-based calculations for estimating glomerular filtration rate (GFR). However, these equations, as well as their combination, have limitations, notably the problem of implausible changes in

Sociala rörelser i motvind : Nordiska sexarbetare och deras allierade 1970–2020

Med växlande framgång har nordiska sexsäljare organiserat sig ända sedan 1970-talet. Kapitlet är en historisk studie av sexarbetar- organisationer i Danmark, Norge och Sverige 1970–2020, med fokus på den svenska rörelsen. Jämförelsen med Danmark och Norge visar på stora skillnader i hur föreningarna kunnat verka i de olika länderna. Speciellt studeras deras mål och syfte, hur lätt eller svårt de

Low- And medium-spin negative-parity bands in the Os 187 nucleus

Low- and medium-spin negative-parity bands of Os187 have been studied using the AFRican Omnipurpose Detector for Innovative Techniques and Experiments (AFRODITE) array, following the W186(He4,3n)Os187 reaction at a beam energy of 37 MeV. In the current work, all the previously known bands have been significantly extended and three new bands have been added to the level scheme. The angular distribu

A stress syndrome prototype reflects type 3 diabetes and ischemic stroke risk : The SABPA study

Type 3 diabetes (T3D) accurately reflects that dementia, e.g., Alzheimer’s disease, represents insulin resistance and neurodegeneration in the brain. Similar retinal microvascular changes were observed in Alzheimer’s and chronic stressed individuals. Hence, we aimed to show that chronic stress relates to T3D dementia signs and retinopathy, ultimately comprising a Stress syndrome prototype reflecti

In community-dwelling women frailty is associated with imminent risk of osteoporotic fractures

Summary: Frailty reflects an accelerated health decline. Frailty is a consequence of fracture and contributes to fracture. Greater frailty was associated with higher fracture risk. Frail women were at immediate risk (within 24 months) of a hip or major fracture. Fracture prevention could be improved by considering frailty status. Introduction: Frailty encompasses the functional decline in multiple

Exploring Emotional Distress, Psychological Traits and Attitudes in Patients with Chronic Migraine Undergoing OnabotulinumtoxinA Prophylaxis versus Withdrawal Treatment

This explorative cross-sectional study aims at exploring emotional distress, psychological profiles, and the attitude towards receiving psychological support in eighty-seven patients with chronic migraine (CM) undergoing OnabotulinumtoxinA prophylactic treatment (OBT-A, n = 40) or withdrawal treatment (WT, n = 47). The outcomes were explored through a specific battery of questionnaires. 25% of pat

Centiloid scaling for quantification of brain amyloid with [18F]flutemetamol using multiple processing methods

INTRODUCTION: A standardised method for quantifying β-amyloid PET tracers would allow comparison across different tracers and different sites. The development of the Centiloid scale has aimed to achieve this, applying a common scale to better aid the diagnosis and prognosis of Alzheimer's disease (AD) and to monitor anti-amyloid therapeutic interventions. Here, we apply the Centiloid method to [18

Orthodontic appliances and MR image artefacts : An exploratory in vitro and in vivo study using 1.5-T and 3-T scanners

Purpose: The aim of this study was to assess the artefacts of 12 fixed orthodontic appliances in magnetic resonance images obtained using 1.5-T and 3-T scanners, and to evaluate different imaging sequences designed to suppress metal artefacts. Materials and Methods: In vitro, study casts of 1 adult with normal occlusion were used. Twelve orthodontic appliances were attached to the study casts and