To capture highly dynamic biological processes at cellular resolution is a recurring challenge in biology. Here we show that combining selective-volume illumination with simultaneous acquisition of orthogonal light fields yields three-dimensional images with high, isotropic spatial resolution and a significant reduction of reconstruction artefacts, thereby overcoming current limitations of light-f

BACKGROUND: It has been proposed that pregnant women and their fetuses may be particularly at risk for poor outcomes due to the coronavirus (COVID-19) pandemic. From the few case series that are available in the literature, women with high risk pregnancies have been associated with higher morbidity. It has been suggested that pregnancy induced immune responses and cardio-vascular changes can exagg

Parkinson’s Disease (PD) is the most common movement disorder and second most common neurodegenerative disease. The principal hallmark of the pathology is represented by a loss of mesencephalic Dopaminergic neurons (mesDA) that reside in the Substantia Nigra pars compacta (SNpc). Another feature of the disease is represented by formation of abnormal protein aggregates, known as Lewy Bodies (LBs),

This paper provides an overview, insights, results and a classification related to development and analyses of case studies within the scientific networking project COST Action TU1402 on the value of Structural Health Monitoring (SHM) information. With an outline of the framework and approaches, a procedure on how to quantify the value of SHM information on the basis of the Bayesian decision theor

This paper describes the assessment of the cost efficiency of risk mitigation strategies for terrorist attacks with Improvised Explosive Devices (IEDs) for an iconic bridge structure. The assessment is performed with a decision theoretical framework building upon very recent advances in the COST Action TU1402 on Quantifying the Value of Structural Heath Monitoring. The decision scenario is formula

Structural monitoring (e.g. structural measurement and damage detection) and inspections have been widely applied as part of structural maintenance. However, the potential of using the obtained information is not yet fully exploited to update the structural reliability and support the maintenance and operation strategy. This paper describes the foundations, limitations, and characteristics of meas

Identifying optimal inspection and repair strategies for offshore jacket structures is a challenging task. We present an approach, which is based on recent developments in the field of risk-based operation and maintenance planning at the structural system level. The approach utilizes heuristics to define inspection and repair strategies at the system level and to reduce the search space of possibl

This paper addresses the effects of the deterioration on the value of damage detection information. The quantification of the value of damage detection information for deteriorated structures is based on Bayesian pre-posterior decision analysis, comprising structural system performance models, consequence, benefit and costs models and damage detection information models throughout the service life

Over the last decade, Unmanned Aerial Vehicles (UAVs) have been used for monitoring construction and operation of civil infrastructure, as well as industrial facilities and power plants. Their operational simplicity along with time-and-cost-related benefits have already rendered them attractive for structural surveying. Nevertheless, the field of UAV research currently lacks a targeted employment

This paper describes the assessment of the cost efficiency of risk mitigation measures for terrorist attacks with Improvised Explosive Devices (IEDs) for an iconic bridge structure. The assessment is performed with a decision theoretical framework building upon very recent advances in the framework of the COST Action TU1402 on Quantifying the Value of Structural Heath Monitoring. The decision scen

This paper addresses how the value of damage detection information depends on key parameters of the Structural Health Monitoring (SHM) system including number of sensors and sensor locations. The Damage Detection System (DDS) provides the information by comparing ambient vibration measurements of a (healthy) reference state with measurements of the current structural system. The performance of DDS

Damage detection systems (DDSs) provide information on the integrity of structural systems in contrast to local information from inspections or non-destructive testing (NDT) techniques. In this paper, an approach is developed that utilizes DDS information to update structural system reliability and integrate this information into risk and decision analyses. The approach includes a novel performanc

Prediction of the service lifetime of concrete structures with respect to chloride ingress involves a number of parameters that are associated with large uncertainties. Hence, full-scale measurements are strongly in demand. This paper begins by summarizing statistical distributions based on measurements taken from the Gimsøystraumen Bridge in Norway. A large number of chloride profiles are availab

Decision analysis is often used to help decision makers choose among alternatives, based on the expected utility associated to each alternative as function of its consequences and potential impacts. Environmental impacts are not always among the prioritized concerns of traditional decision making. This has fostered the development of several environmental problems and is nowadays a reason of conce

This article introduces an approach and framework for the quantification of the value of structural health monitoring (SHM) in the context of the structural risk and integrity management for systems. The quantification of the value of SHM builds upon the Bayesian decision and utility theory, which facilitates the assessment of the value of information associated with SHM. The principal approach fo

The parameters relevant for prediction of service lifetime with respect to chloride ingress are associated with large uncertainties. Full-scale measurements are in demand for conditions which are as homogeneous as possible. The present paper first summarizes statistical distributions which are obtained based on measurements from the Gimsøystraumen bridge in Norway. These probability distributions

This paper summarizes the development of Value of Structural Health Monitoring (SHM) Information analyses and introduces the development, objectives and approaches of the COST Action TU1402 on this topic. SHM research and engineering has been focused on the extraction of loading, degradation and structural features for damage detection and condition assessment, system identification and model upda

This paper addresses the quantification of the value of damage detection system and algorithm information on the basis of Value of Information (VoI) analysis to enhance the benefit of damage detection information by providing the basis for its optimization before it is performed and implemented. The approach of the quantification the value of damage detection information builds upon the Bayesian d

Asset integrity and management is an important part of the oil and gas industry especially for existing offshore structures. With declining oil price, the production rate is an important factor to be maintained that makes integrity of the structures one of the main concerns. Reliability based and risk- based inspection (RRBI) constitutes an efficient method to optimize inspection planning. Basing