Peripheral Immune Cell Signatures and Risk for Alzheimer’s Disease
Alzheimer’s Disease (AD), a neurodegenerative disease, defined by abnormal accumulation of proteins, both extracellularly (senile plaques, consisting of amyloid-beta(Aβ) accumulation) and intracellularly (neurofibrillary tangles, formed by Tau protein). Several studies demonstrate that the immune cells play a central role in the pathogenesis of AD, but it is not known if immune cells from the peri