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Research from King’s College in London, UK, and Lund University in Sweden could explain why diabetes drugs which have worked in animal experiments are not equally successful in humans. The researchers discovered differences – but also unknown similarities – in the function of insulin-producing beta cells. The team have mapped a category of receptors, known as G protein-coupled receptors, which con

https://www.ludc.lu.se/article/new-research-describes-differences-between-mice-and-humans - 2025-10-07

Taking advantage of a novel sub-classification of diabetes LUDC-IRC, a newly launched collaboration between academia, the health care system and industry, aims at delivering precision medicine in diabetes.  - We have set the bar high. We very specifically aim at making a difference for diabetes patients by the end of this eight year program. We need to find smart ways to use all resources we colle

https://www.ludc.lu.se/article/ludc-irc-ready-take - 2025-10-07

Can insulin taken as an infant in small doses together with food render the immune system used to insulin and thus prevent type 1 diabetes? Can a gluten-free diet and probiotics prevent celiac disease (so called gluten intolerance)? These questions will be asked by two separate studies that are being planned at Lund University in Sweden. A new comprehensive screening of newborn babies in southern

https://www.ludc.lu.se/article/newborn-babies-be-screened-studies-type-1-diabetes-and-celiac-disease-gluten-intolerance - 2025-10-07

Food researchers at Lund University in Sweden have discovered that consuming small amounts of chromium mixed with certain amino acids before eating is healthy. Why? Well, this mixture diluted in water suppresses the blood sugar spike that occurs when we eat. Now, they are hoping that the drink – which tastes like ordinary mineral water – will be able to compete with soft drinks and flavoured water

https://www.ludc.lu.se/article/new-drink-keeps-blood-sugar-check - 2025-10-07

There has been a fear that the swine flu vaccine, Pandemrix, would increase the risk of autoimmune diseases other than narcolepsy. However, a new study of children from Sweden and Finland shows that the vaccine increased neither the risk of developing autoantibodies against insulin-producing beta cells nor the occurrence of type 1 diabetes. “On the contrary, the risk was reduced among vaccinated c

https://www.ludc.lu.se/article/risk-type-1-diabetes-not-increased-swine-flu-vaccine-pandemrix - 2025-10-07

Researchers at Lund University in Sweden have found that the presence of death receptors in the blood can be used to directly measure the risk of developing cardiovascular diseases and type 2 diabetes. “We see that people with known risk factors such as high blood sugar and high blood fats also have heightened death receptor levels”, says Professor Jan Nilsson who led the study. Death receptors ar

https://www.ludc.lu.se/article/death-receptors-new-markers-type-2-diabetes-and-cardiovascular-disease - 2025-10-07

December 4-5, nordic researchers gathered in Malmö to discuss future challenges in precision medicine, a research field where diagnosis and treatment are based on the individual´s genetic and biological conditions. Focus is on our common and increasing diseases diabetes, cardiovascular disease, cancer and psychiatric diagnosis. "The goal of the meeting is to bring together mordic stakeholders in p

https://www.ludc.lu.se/article/nordic-conference-malmo-about-precision-medicine-future - 2025-10-07

A completely new classification of diabetes which also predicts the risk of serious complications and provides treatment suggestions. We are now seeing the first results of ANDIS – a study covering all newly diagnosed diabetics in southern Sweden — published in The Lancet Diabetes & Endocrinology. The major difference from today’s classification is that type 2 diabetes actually consists of several

https://www.ludc.lu.se/article/paradigm-shift-diagnosis-diabetes - 2025-10-07

This study extends TCAL by disentangling causes of death contributions. The strength of the approach is that it allows identification of mortality differences in cohorts with members still alive, as well as identification of which ages and causes of death contribute to mortality differentials between populations. Read the paper at https://academic.oup.com/ije/article/49/5/1712/5721433

https://www.lupop.lu.se/article/reflection-modern-methods-cause-death-decomposition-cohort-survival-comparisons - 2025-10-07

Advances in synthetic control methods bring new opportunities to conduct rigorous research in evaluating public health interventions. However, incorporating synthetic controls in interrupted time series studies may not always nullify important threats to validity nor improve causal inference. Read the paper at https://academic.oup.com/ije/article/49/6/2010/5917161

https://www.lupop.lu.se/article/can-synthetic-controls-improve-causal-inference-interrupted-time-series-evaluations-public-health - 2025-10-07

Concerns have been expressed over standards of statistical interpretation. Results with P <0.05 are often referred to as ‘significant’ which, in plain English, implies important. This leads some people directly into the misconception that this provides proof that associations are clinically relevant. Read the paper at https://academic.oup.com/ije/article/49/6/2083/5876177

https://www.lupop.lu.se/article/reflection-modern-methods-statistics-education-beyond-significance-novel-plain-english - 2025-10-07

Standard errors are usually calculated based on assumptions underpinning the statistical model used in the estimation. However, there are situations in which some assumptions of the statistical model including the variance or covariance of the outcome across observations are violated, which leads to biased standard errors. Read the paper at https://academic.oup.com/ije/article/50/1/346/6044447

https://www.lupop.lu.se/article/reflection-modern-methods-demystifying-robust-standard-errors-epidemiologists - 2025-10-07

The IDAG allows for a both intuitive and stringent way of illustrating interactions. It helps to distinguish between causal and non-causal mechanisms behind effect variation. Read the paper at https://academic.oup.com/ije/article/50/2/613/5998421

https://www.lupop.lu.se/article/directed-acyclic-graph-interactions - 2025-10-07

Directed acyclic graphs (DAGs) are an increasingly popular approach for identifying confounding variables that require conditioning when estimating causal effects. This review examined the use of DAGs in applied health research to inform recommendations for improving their transparency and utility in future research. Read the paper at https://academic.oup.com/ije/article/50/2/620/6012812

https://www.lupop.lu.se/article/use-directed-acyclic-graphs-dags-identify-confounders-applied-health-research-review-and - 2025-10-07

Statistical learning methods beyond generalized linear models, such as shrinkage methods or kernel smoothing methods, are being increasingly implemented in public health research and epidemiology because they can perform better in instances with complex or high-dimensional data—settings in which traditional statistical methods fail. Read the paper at https://academic.oup.com/ije/article/50/2/685/6

https://www.lupop.lu.se/article/reflection-modern-methods-good-practices-applied-statistical-learning-epidemiology - 2025-10-07

The ambition is to provide one of the first large-scale European family studies with individual data across three generations, which could deepen our knowledge about the role of family traits for chronic disease and its underlying mechanisms. Read the paper at https://link.springer.com/article/10.1007/s10654-020-00695-4

https://www.lupop.lu.se/article/malmo-offspring-study-mos-design-methods-and-first-results - 2025-10-07

The network will add value to participating cohorts by increasing statistical power and exposure heterogeneity, as well as facilitating cross-cohort comparisons, cross-validation and replication. Our aim is to motivate other cohorts to join the network and encourage the use of the EU Child Cohort Network by the wider research community. Read the paper at https://link.springer.com/article/10.1007%2

https://www.lupop.lu.se/article/eu-child-cohort-networks-core-data-establishing-set-findable-accessible-interoperable-and-re-usable - 2025-10-07

Nytt stöd för mer inkluderande forskningsfinansiering Den 27 april lanserade forskningsfinansiärerna Formas, Forte, Vinnova och Energimyndigheten ett nytt, webbaserat processtöd för att nå ut bättre till sökande från en mångfald av discipliner och sektorer och även för att stärka samverkan mellan forskning och det omgivande samhället.Pressmeddelandet finns här och själva sidan på humsamverkan.se.

https://www.lupop.lu.se/article/humsamverkan - 2025-10-07

Health workers invest major time recording register data for maternal and newborn core health indicators. Improving data quality requires standardised register designs streamlined to capture only necessary data elements. Consistent implementation processes are also needed. Read the paper at https://bmcpregnancychildbirth.biomedcentral.com/articles/10.1186/s1288…

https://www.lupop.lu.se/article/barriers-and-enablers-routine-register-data-collection-newborns-and-mothers - 2025-10-07

Mediation analysis seeks to explain the pathway(s) through which an exposure affects an outcome. Traditional, non-instrumental variable methods for mediation analysis experience a number of methodological difficulties, including bias due to confounding between an exposure, mediator and outcome and measurement error. Mendelian randomisation (MR) can be used to improve causal inference for mediation

https://www.lupop.lu.se/article/mendelian-randomisation-mediation-analysis-current-methods-and-challenges-implementation - 2025-10-07