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Age-Dependent Alpha-Synuclein Accumulation and Phosphorylation in the Enteric Nervous System in a Transgenic Mouse Model of Parkinson’s Disease

The enteric nervous system (ENS) controls the function of the gastrointestinal tract and has been implicated in various diseases, including Parkinson’s disease (PD). PD is a neurodegenerative disease with Lewy bodies (LBs) and Lewy neurites (LNs) as the main pathological features. In addition to the typical motor symptoms in PD, attention has been drawn to non-motor symptoms, such as constipation,

The Inherent Complexity of Agglomeration : Essays on the self-organization of urban economies

Den här avhandlingen kombinerar vetenskapen om komplexa adaptiva system med ekonomiska geografi för att beskriva och undersöka självorganiserande principer och drag i täta urbana ekonomier, särskilt med avseende på flöden av information och kunskap mellan människor som ger upphov till produktivitetsrelaterade externaliteter. Avhandlingen består av en kappa som presenterar det övergripande ramverkeThis doctoral thesis combines complexity science and economic geography in order to explore bottom-up, self-organizing principles within urban economies, in particular in relation to the flow of information and knowledge between people. The thesis consists of a kappa that covers the general theoretical framework and four papers. The papers cover urban scaling and intra-urban scaling analysis, loca

Legal Facts in Argumentation-Based Litigation Games

This paper analyzes legal fact-argumentation in the framework of the argumentation-based litigation game (ALG) by Xiong (Leg Sci 370(9):16–19, 2012). Rather than as an ontological one, an ALG treats a legal fact as a fact-qua-claim whose acceptability depends on the reasons supporting it. In constructing their facts-qua-claims, parties to an ALG must interact to maintain a game-theoretic equilibri

Modelling past, present and future peatland carbon accumulation across the pan-Arctic region

Most northern peatlands developed during the Holocene, sequestering large amounts of carbon in terrestrial ecosystems. However, recent syntheses have highlighted the gaps in our understanding of peatland carbon accumulation. Assessments of the long-Term carbon accumulation rate and possible warming-driven changes in these accumulation rates can therefore benefit from process-based modelling studie

Quantification of the Intracellular Life Time of Water Molecules to Measure Transport Rates of Human Aquaglyceroporins

Orthodox aquaporins are transmembrane channel proteins that facilitate rapid diffusion of water, while aquaglyceroporins facilitate the diffusion of small uncharged molecules such as glycerol and arsenic trioxide. Aquaglyceroporins play important roles in human physiology, in particular for glycerol metabolism and arsenic detoxification. We have developed a unique system applying the strain of the

Particulate sulfur in the upper troposphere and lowermost stratosphere - Sources and climate forcing

This study is based on fine-mode aerosol samples collected in the upper troposphere (UT) and the lowermost stratosphere (LMS) of the Northern Hemisphere extratropics during monthly intercontinental flights at 8.8-12 km altitude of the IAGOS-CARIBIC platform in the time period 1999-2014. The samples were analyzed for a large number of chemical elements using the accelerator-based methods PIXE (part

Isoprenoid emission response to changing light conditions of English oak, European beech and Norway spruce

Light is an important environmental factor controlling biogenic volatile organic compound (BVOC) emissions, but in natural conditions its impact is hard to separate from other influential factors such as temperature. We studied the light response of foliar BVOC emissions, photosynthesis and stomatal conductance on three common European tree species, namely English oak (Quercus robur), European bee

Affective–associative two-process theory : a neurocomputational account of partial reinforcement extinction effects

The partial reinforcement extinction effect (PREE) is an experimentally established phenomenon: behavioural response to a given stimulus is more persistent when previously inconsistently rewarded than when consistently rewarded. This phenomenon is, however, controversial in animal/human learning theory. Contradictory findings exist regarding when the PREE occurs. One body of research has found a w

Greenhouse gas performance of biochemical biodiesel production from straw : Soil organic carbon changes and time-dependent climate impact

Background: Use of bio-based diesel is increasing in Europe. It is currently produced from oilseed crops, but can also be generated from lignocellulosic biomass such as straw. However, removing straw affects soil organic carbon (SOC), with potential consequences for the climate impact of the biofuel. This study assessed the climate impacts and energy balance of biodiesel production from straw usin

Effect of oral pre-meal administration of betaglucans on glycaemic control and variability in subjects with type 1 diabetes

We conducted a double-blind placebo-controlled crossover pilot study to investigate the effect of oat betaglucans (β-glucan) on glycaemic control and variability in adults with type 1 diabetes (T1D; n = 14). Stomacol® tablets (1.53 g of β-glucan) or placebo (Plac) were administered three times daily before meals for two weeks. Glucose levels were monitored during the second week by continuous gluc

Random spectral measure for non Gaussian moving averages

We study the distribution of phases and amplitudes for the spectral representation of weighted moving averages of a general noise measure. The simple independent structure, known for the Gaussian case, and involving Rayleigh amplitude and uniform phase distributions, is lost for the non Gaussian noise case. We show that the amplitude/phase distributions exhibit a rich and more complex structure de

Impact of a Tertiary Eligibility Threshold on Tertiary Education and Earnings : A Discontinuity Approach

This study evaluates the impact of achieving tertiary eligibility in upper-secondary education on tertiary education and earnings in Sweden. Using a regression discontinuity design, we estimate the impact of tertiary eligibility and show that it has a substantial impact on the probability of enrolling in tertiary education. For students who achieve tertiary eligibility, the probability of enrollin

Evolutionary Games and Matching Rules

This study considers evolutionary models with non-uniformly random matching when interaction occurs in groups of n>=2 individuals. In such models, groups with different compositions of individuals generally co-exist and the reproductive success (fitness) of a specific strategy – and consequently long-run behavior in the population – varies with the frequencies of different group types. These frequ

‘Why not make films for New York?’ : The interaction between cultural, political and commercial perspectives in Swedish film policy 1963–2013

During the last two decades or so, film support, film policy and the public financing of audiovisual production in Scandinavia and particularly Sweden have undergone extensive transformation. In diverse ways, these changes can be seen as responses to globalization, to increased sub-national regional independence as well as to the emerging idea of nurturing ‘creative industries’ taking hold. They m

The perception of aquaculture on the Swedish West Coast

Efforts are on the way on the Swedish West Coast to develop the capacity for cultivation of marine resources, notably of kelps. Given that this is a region of great natural and national heritage, public opposition to marine developments has been identified as a possible risk factor. This survey thus sought to shed light on awareness levels, perceptions of different types of aquaculture and on reacEfforts are on the way on the Swedish West Coast to develop the capacity for cultivation of marine resources, notably of kelps. Given that this is a region of great natural and national heritage, public opposition to marine developments has been identified as a possible risk factor. This survey thus sought to shed light on awareness levels, perceptions of different types of aquaculture and on reac

Design and Characterization of Functional Structures for Electromagnetic Waves

This dissertation deals with design and characterization of functional structures for scattering of electromagnetic waves. An abundance of these structures can be found in nature, such as the structural coloration in the feathers of a peacock, the scales of butterflies and the shell of scarab beetles. Human design of structures providing specific interactions with electromagnetic waves have a long