Isolation of long-term hematopoietic stem cell (HSC) is possible by utilizing flow cytometry with multiple cell surface markers. However, those cell surface phenotypes do not represent functional HSCs after in vitro culture. Here we show that cultured HSCs express mast cell-related genes including Cd244. After in vitro culture, phenotypic HSCs were divided into CD244- and CD244+ subpopulations, an

Background: Repetitive head injury in contact sports is associated with cognitive, neurobehavioral, and motor impairments and linked to a unique neurodegenerative disorder: chronic traumatic encephalopathy (CTE). As the clinical presentation is variable, risk factors are heterogeneous, and diagnostic biomarkers are not yet established, the diagnostic process of CTE remains a challenge. The general

Background: This study will explore implementation mechanisms through which a single implementation strategy and a multifaceted implementation strategy operate to affect the implementation outcome, which is fidelity to the Guideline For The Prevention of Mental Ill Health within schools. The guideline gives recommendations on how workplaces can prevent mental ill health among their personnel by ma

Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To determine the effects of non-opioid analgesics in neonates (term or preterm) exposed to procedural pain compared to placebo or no drug, non-pharmacological intervention, other analgesics, or different routes of administration.

INTRODUCTION: Collagenous colitis (CC) is a common cause of chronic diarrhea and is characterized by a subepithelial thickened collagen layer in the colonic mucosa. It shares many of the characteristics found in autoimmune diseases, but no autoantibodies have been identified. In CC, an imbalance in collagen turnover is evident. The purpose of the present study was to investigate whether any collag

During March 2020 a large-span arena, Tarfalahallen, collapsed. The main load-bearing girders with a 54 m span were high and slender glulam trussed beams, supported from below by a cable system via vertical struts. Investigations concluded that the failure was initiated by out-of-plane buckling of the struts and slender beam, in spite of lateral stabilization by steel roof sheeting at the top edge

Vad ska en surrogatmamma känna inför fostret hon bär i sin mage? Hur ska en hårt arbetande förälder förhålla sig till faktumet att nannyn eller kalasfixaren vet bäst hur deras barn vill ha sitt kalas? Kan en flygvärdinna eller en socialarbetare visa den irritation hon känner inför en otrevlig kund eller klient? Vilka känslor är legitima att visa upp i olika situationer och vilka behöver tryckas ne

After a 7-year slowdown in economic growth in the previous decade, LAC opened this decade with the adverse effects of Covid. The economic slowdown and the health crisis jeopardized the SDGs’ implementation in the region. In this chapter, the authors revisit the old question of whether the previous decade of LAC is another lost decade, mainly adding the environmental dimension to the economic and s

This article reflects on Max Weber’s idea of disenchantment in relation to the material turn within contemporary religious studies. In the first part, I return to the two most famous texts in which Weber uses the concept, with particular attention to the historical context in which these texts were penned. In the following part, I discuss some of the contemporary efforts to engage critically with

Purpose/Background: Appendectomy is the standard treatment of acute appendicitis (AA) but conservative treatment has gained success. The need for follow-up after conservatively treated AA is unclear. Hypothesis/Aim: This study evaluates follow-up, recurrence and appendiceal malignancy in conservatively treated AA. Methods/Interventions: This retrospective study included patients with conservativel

STUDY QUESTION: Does previous bariatric surgery (BS) in women affect cumulative live birth rate in IVF?SUMMARY ANSWER: Women having had BS seem to have the same cumulative live birth rate as non-operated women of the same BMI at IVF treatment.WHAT IS KNOWN ALREADY: Because of the perinatal risks of obesity to mother and infant as well as impaired outcomes of IVF, obese women are advised to reduce

STUDY QUESTION: Is the chance of childbirth, and risk of infertility, pregnancy loss and need for assisted reproduction different for women with asthma compared to women without asthma?SUMMARY ANSWER: Women with asthma had comparable chances of giving birth compared to the reference population, however, their risk of both infertility and pregnancy loss, as well their need for medically assisted re

Om relationen mellan Homo sapiens och Homo sapiens neanderthalensis

In modern society, the consumption of fossil fuels has been increasing drastically, leading to significant emissions of carbondioxide (CO2), air pollution, global warming, and political and economic imbalances. This has increased the interest inrenewable and sustainable energy sources such as wind- and hydropower, solar energy, and in energy conversion by fuel celltechnology, and water electrolyse

Previous research on A/B testing and continuous experimentation has mostly focused on large-scale settings with company-external customers. However, work efficiency and satisfaction for company coworkers may be highly related to internal tools and their fit-for-use. In this study, we therefore explore A/B testing for online services exclusively used by company co-workers. We A/B tested two version

Automated testing is a safeguard against software regression and provides huge benefits. However, it is yet a challenging subject. Among others, there is a risk that the test cases are too specific, thus making them inefficient. There are many forms of undesirable behaviour that are compatible with a typical program’s specification, that however, harm users. An efficient test should provide most p

Rapid internationalization of European higher education has resulted in a considerable increase in the number of English-medium instruction (EMI) degree programs now implemented at all levels of instruction. While this change of medium provides increased academic opportunities for all university stakeholders, the use of English by non-native speakers for teaching and learning in non-Anglosphere co

Context: The low quality and small size of samples in empirical studies in software engineering hamper the interpretation and generalization of their results. Therefore, enlarging sample sizes and improving their quality represent an important research challenge. Goal: We aim to define a conceptual framework, including requirements for establishing adequate sources for sampling subjects in softwar

Background: Mobile health (mHealth), wearable activity trackers (WATs) and other digital solutions could support physical activity (PA) in individuals with hip and knee osteoarthritis (OA), but little is described regarding experiences and perceptions of digital support and the use of WAT to self-monitor PA. Thus, the aim of this study was to explore the experiences of using a WAT to monitor PA an