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Nanocarbon oxidation in the environmental transmission electron microscope : Disentangling the role of the electron beam

Environmental transmission electron microscopy (ETEM) can provide unique insights into nanocarbon oxidation processes through atomic resolution and real time imaging of materials at high temperatures in reactive atmospheres. However, the electron beam can also influence the reaction rates, and even alter the processes entirely, complicating the interpretation of the in situ observations. Many mech

Predicting evolution over multiple generations in deteriorating environments using evolutionarily explicit Integral Projection Models

Human impacts on the natural world often generate environmental trends that can have detrimental effects on distributions of phenotypic traits. We do not have a good understanding of how deteriorating environments might impact evolutionary trajectories across multiple generations, even though effects of environmental trends are often significant in the statistical quantitative genetic analyses of

Statistical analysis of pairs of rotational bands in "odd and even" nuclei at normal deformation

A statistical analysis has been done for the variation of the moment of inertia in pairs of rotational bands between odd-A and adjacent A - 1 even-even nuclei at normal deformation. A smooth distribution centered at small differences or no difference is obtained but apart from this, no special surplus of so-called identical bands is found. Furthermore, it is found that upsloping orbitals are predo

Structure of neutron-rich s-d shell nuclei

States in neutron-rich s-d shell nuclei were populated in the reaction of a 14C beam at Elab = 22 MeV on a 14C target. Coincidences between γ rays and either other γ rays or light charged particles were measured. γ rays in coincidence with protons established levels at 66.8, 1730, 1823, and 2219 keV in 27Na. The states are compared with calculations based on the s-d shell model and the cranked Nil

Strong population of a superdeformed band in Eu142

A superdeformed band has been found in Eu142. It is populated with 1.2(2)% of the total -ray intensity that decayed into Eu142 via the reaction Sn120(27Al,5n)142Eu at 152 MeV. The strength of the band is similar to that previously reported in Eu143, where the superdeformed band is populated with an intensity of 1.1(1)%. This is unexpected, since both total Routhian surface (TRS) and cranked modifi

A power analysis for model-X knockoffs with ℓ p -regularized statistics

Variable selection properties of procedures utilizing penalized-likelihood estimates is a central topic in the study of high-dimensional linear regression problems. Existing literature emphasizes the quality of ranking of the variables by such procedures as reflected in the receiver operating characteristic curve or in prediction performance. Specifically, recent works have harnessed modern theory

Inactive S. aureus Cas9 downregulates alpha-synuclein and reduces mtDNA damage and oxidative stress levels in human stem cell model of Parkinson’s disease

Parkinson’s disease (PD) is one of the most common neurodegenerative diseases, but no disease modifying therapies have been successful in clinical translation presenting a major unmet medical need. A promising target is alpha-synuclein or its aggregated form, which accumulates in the brain of PD patients as Lewy bodies. While it is not entirely clear which alpha-synuclein protein species is diseas

Hyphal exploration strategies and habitat modification of an arbuscular mycorrhizal fungus in microengineered soil chips

Arbuscular mycorrhizal fungi (AMF) are considered ecosystem engineers, but the interactions of their mycelium with their immediate surroundings are largely unknown. In this study, we used microfluidic chips, simulating artificial soil structures, to study foraging strategies and habitat modification of Rhizophagus irregularis symbiotically associated to carrot roots. AMF hyphae foraged over long d

The C-terminal domain of the antiamyloid chaperone DNAJB6 binds to amyloid-β peptide fibrils and inhibits secondary nucleation

The DNAJB6 chaperone inhibits fibril formation of aggregation-prone client peptides through interaction with aggregated and oligomeric forms of the amyloid peptides. Here, we studied the role of its C-terminal domain (CTD) using constructs comprising either the entire CTD or the first two or all four of the CTD β-strands grafted onto a scaffold protein. Each construct was expressed as WT and as a

Inequalities in water, sanitation and hygiene : Challenges and opportunities for measurement and monitoring

While there is significant awareness of the importance of addressing water, sanitation and hygiene (WASH) inequalities, measurement continues to present a challenge. Addressing how inequalities are measured, tracked and communicated is fundamental to accelerating progress in ensuring universal WASH coverage and associated benefits. We review how WASH inequalities have been measured and monitored t

Can L2 motivation be modelled as a self-system? A critical assessment

Some two decades ago, Dörnyei (2005) proposed that motivation for L2 learning could be modelled as a self-system. Despite the profound influence of Dörnyei's scholarship and impact of the L2 Motivational Self System (L2MSS) model, the fundamental premise that motivation for L2 learning can constitute a self-system has escaped critical scrutiny. Highlighting how the self-system constitutes a framew

Escape to the future – a qualitative study of physicians’ views on the work environment, education, and support in a digital context

Background: The use of remote services such as video consultations (VCs) has increased significantly in the wake of the COVID-19 pandemic. In Sweden, private healthcare providers offering VCs have grown substantially since 2016 and have been controversial. Few studies have focused on physicians’ experiences providing care in this context. Our aim was to study physicians’ experiences of VCs, focusi

Tourism, cyclones, hurricanes and flooding

This book explores the relationship between tourism and high-magnitude storm events, including cyclones, hurricanes and typhoons and flooding, across all stages of a disaster. It considers the measures available to manage tourism after major storms and floods, examines the means to mitigate the potential impacts of these disasters on tourism, and provides insights into the ethical and socioeconomi

Genetic constraints in genes exhibiting splicing plasticity in facultative diapause

Phenotypic plasticity is produced and maintained by processes regulating the transcriptome. While differential gene expression is among the most important of these processes, relatively little is known about other sources of transcriptional variation. Previous work suggests that alternative splicing plays an extensive and functionally unique role in transcriptional plasticity, though plastically s

Intracellular C3 protects β-cells from IL-1β-driven cytotoxicity via interaction with Fyn-related kinase

One of the hallmarks of type 1 but also type 2 diabetes is pancreatic islet inflammation, associated with altered pancreatic islet function and structure, if unresolved. IL-1β is a proinflammatory cytokine which detrimentally affects β-cell function. In the course of diabetes, complement components, including the central complement protein C3, are deregulated. Previously, we reported high C3 expre

Life’s Essential 8 in relation to self-rated health and health-related quality of life in a large population-based sample : the SCAPIS project

Purpose: To monitor cardiovascular health, in 2022, the American Heart Association (AHA) updated the construct “Life’s Simple 7” (LS7) to “Life’s Essential 8” (LE8). This study aims to analyze the associations and capacity of discrimination of LE8 and LS7 in relation to self-rated health (SRH) and health-related quality of life (HRQoL). Methods: This study from the Swedish CArdioPulmonary bioImage

Implications of policy changes for coastal landscape patterns and sustainability in Eastern China

Context: The capacity of a landscape to maintain multifunctionality through ongoing pressures relates to its sustainability and is affected by land use policy and environmental changes. In coastal zones, limited empirical evidence exists regarding the impact of macro-level policy changes on local landscapes and their resulting temporal and spatial responses. Objectives: This paper investigates the

GLOBAL LEADERSHIP: Book 16 - THE INTERNATIONAL BUSINESS INTERACTION SERIES

Leadership is complex, and leadership in a global business is no less complex. To a great extent, the challenge in leadership is to look at what requirements the specific management task poses, and what opportunities it creates, and to be aware of what expectations and ideas are present, for example in the form of cultural values within a given organization. Greater complexity and variation in app

The effect of surface topography on the ball-rolling ability of Kheper lamarcki (Scarabaeidae)

The most effective way to avoid intense inter- and intra-specific competition at the dung source, and to increase the distance to the other competitors, is to follow a single straight bearing. While ball-rolling dung beetles manage to roll their dung balls along nearly perfect straight paths when traversing flat terrain, the paths that they take when traversing more complex (natural) terrain are n

Modeling stress-induced responses : plasticity in continuous state space and gradual clonal evolution

Mathematical models of cancer and bacterial evolution have generally stemmed from a gene-centric framework, assuming clonal evolution via acquisition of resistance-conferring mutations and selection of their corresponding subpopulations. More recently, the role of phenotypic plasticity has been recognized and models accounting for phenotypic switching between discrete cell states (e.g., epithelial