Background: Previous studies showed that lifestyle behaviors (cigarette smoking, alcohol, coffee) are inversely associated with Parkinson's disease (PD). The prodromal phase of PD raises the possibility that these associations may be explained by reverse causation. Objective: To examine associations of lifestyle behaviors with PD using two-sample Mendelian randomisation (MR) and the potential for

The effect of an annular, piston bowl-rim cavity on in-cylinder and engine-out soot emissions is measured in a heavy-duty, optically accessible, single-cylinder diesel engine using in-cylinder soot diagnostics and exhaust smoke emission measurements. The baseline piston configuration consists of a right-cylindrical bowl, while the cavity-piston configuration features an additional annular cavity t

A commercially available fuel, E85, a blend of ~85% ethanol and ~15% gasoline, can be a viable substitute for fossil fuels in internal combustion engines in order to achieve a reduction of the greenhouse gas (GHG) emissions. Ethanol is traditionally made of biomass, which makes it a part of the food-feed-fuel competition. New processes that reuse waste products from other industries have recently

Importance: Novel plasma biomarkers, especially phosphorylated tau (p-tau), can detect brain tau aggregates in Alzheimer disease. Objective: To determine which plasma biomarker combinations can accurately detect tau pathological brain changes in Down syndrome (DS). Design, Setting, and Participants: The cross-sectional, multicenter Alzheimer's Biomarker Consortium-Down Syndrome study included adul

Swedish lexical word accents have been repeatedly said to have a low functional load. Even so, the language has kept these tones ever since they emerged probably over a thousand years ago. This article proposes that the primary function of word accents is for listeners to be able to predict upcoming morphological structures and narrow down the lexical competition rather than being lexically distinSwedish lexical word accents have been repeatedly said to have a lowfunctional load. Even so, the language has kept these tones ever sincethey emerged probably over a thousand years ago. This article proposesthat the primary function of word accents is for listeners to be ableto predict upcoming morphological structures and narrow down thelexical competition rather than being lexically distinctive

Human in vitro models of neural tissue with tunable microenvironment and defined spatial arrangement are needed to facilitate studies of brain development and disease. Towards this end, embedded printing inside granular gels holds great promise as it allows precise patterning of extremely soft tissue constructs. However, granular printing support formulations are restricted to only a handful of ma

To promote human flourishing throughout society, opportunities for arts participation must encompass all citizens. A primary means to promote this is arts education and activities for schoolchildren. Equal opportunities for participation are currently not enjoyed by students with disabilities. In a population-based and cross-sectional study carried out on a 2016 public-health survey including 27,3

The work environment and especially the psychosocial work environment influence the mental and physical well-being of employees. The aim of this study was to identify and analyse the state of knowledge regarding nurses’ work situation, health, and person-centred work during the COVID-19 pandemic through a systematic review. Methods: Systematic Review, nine included articles. The theoretical swAge

Background: The Parkinson Disease (PD) Home Diary (HD) is a commonly used clinical outcome measure, but it has not been extensively compared to direct assessments by experienced observers.Objective: Validation of patient-reported HD by investigating the agreement between motor state assessments by patients and observers.Methods: This observational study included patients with PD and motor fluctuat

Essays in this Issue of Shuddhashar centralize the roles and powers of documents (and the lack of ‘proper’ documents). In parallel, this essay highlights two short stories to show how the power of documents shapes subaltern lives. I dissect the dichotomous dis/possession of documents around which urban poor’s lives are organised. While the state institutions are required to protect and care about

Aims:Swedish public health reports have repeatedly provided information about socio-economic inequalities in sedentary leisure time, despite that, in the interest of health equity, physical activity should be equally distributed in the population. Such public health reports, however, neither consider the intersection of multiple socio-demographic factors nor the individual heterogeneity around gro

The article intervenes in discussions on lay knowledge production about health in the Internet era, through the case of a group of women claiming that their use of copper intrauterine devices has led to systemic side effects. Based on online group interviews and written essays, we examine how women embracing these knowledge claims navigate various sources of information, focusing on the role of sc

Recent divergence can obscure species boundaries among closely related taxa. Silene section Italicae (Caryophyllaceae) has been taxonomically controversial, with about 30 species described. We investigate species delimitation within this section using 500 specimens sequenced for one nuclear and two plastid markers. Despite the use of a small number of genes, the large number of sequenced samples

This paper presents a search for decays of the Higgs boson with a mass of 125 GeV into a pair of new pseudoscalar particles, H→aa, where one a-boson decays into a b-quark pair and the other into a muon pair. The search uses 139 fb-1 of proton-proton collision data at a center-of-mass energy of s=13 TeV recorded between 2015 and 2018 by the ATLAS experiment at the LHC. A narrow dimuon resonance is

A search optimized for new heavy particles decaying to two b-quarks and produced in association with additional b-quarks is reported. The sensitivity is improved by b-tagging at least one lower-pT jet in addition to the two highest-pT jets. The data used in this search correspond to an integrated luminosity of 103 fb-1 collected with a dedicated trijet trigger during the 2017 and 2018 s=13 TeV pro

Context. Ultra-short period planets undergo strong tidal interactions with their host star which lead to planet deformation and orbital tidal decay. Aims. WASP-103b is the exoplanet with the highest expected deformation signature in its transit light curve and one of the shortest expected spiral-in times. Measuring the tidal deformation of the planet would allow us to estimate the second degree fl

A search for lepton-flavor-violating Z→eτ and Z→μτ decays with pp collision data recorded by the ATLAS detector at the LHC is presented. This analysis uses 139 fb-1 of Run 2 pp collisions at s=13 TeV and is combined with the results of a similar ATLAS search in the final state in which the τ lepton decays hadronically, using the same data set as well as Run 1 data. The addition of leptonically dec

A measurement of dielectron production in proton-proton (pp) collisions at s=13 TeV, recorded with the ALICE detector at the CERN LHC, is presented in this Letter. The data set was recorded with a reduced magnetic solenoid field. This enables the investigation of a kinematic domain at low dielectron (ee) invariant mass mee and pair transverse momentum pT,ee that was previously inaccessible at the

This study analyzes some of the factors that facilitate and complicate advanced legal teaching in human rights as a subject of international law. The main objective is to offer a reflection on the challenges faced by the teacher in this field and which arise as a result of the expansion, diversification, and confrontation of the subject taught. According to the argument developed, a classical or t

An increasing number of litigations before the International Court of Justice (ICJ) concerns situations involving serious crimes (genocide, crimes against humanity and war crimes). However, to date, several of these litigations have failed to deliver justice in the form of reparations to the victims of these crimes. Two recurrent legal obstacles impede effective results: the limits imposed on this