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This study is designed to evaluate the treatment effect of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) and human mesenchymal stem cells (hMSC) on axonal regeneration in experimental rat sciatic nerve damage, and compare the results of this modality with autologous nerve grafting. In Spraque-Dawley albino rats, 10-mm-long experimental nerve gaps were created. Three groups were constitute

In order to understand peripheral nerve dysfunction, and to follow neuronal regeneration, basic sciences of the peripheral nerve should be understood completely. A surgeon who operates on "nerves" uses this knowledge, especially the organization of the peripheral nerve, in nerve reconstructions. When a nerve has been injured, the goal of surgical repair is generally to reapproximate the ends of th

Endoscopic transsphenoidal surgery is emerging as a minimally invasive and maximally effective procedure for pituitary adenomas. In this report we analyzed the complications in 624 procedures of endonasal transsphenoidal endoscopic surgery in the treatment of 570 patients with pituitary adenomas. The leading author (MB) operated pituitary adenomas via pure endoscopic endonasal transsphenoidal surg

Objective: This study aims to investigate the degree of biocompatibility and neuroregeneration of a polymer tube, poly-3-hydroxyoctanoate (PHO) in nerve gap repair. Methods: Forty Wistar Albino male rats were randomized into two groups: autologous nerve gap repair group and PHO tube repair group. In each group, a 10-mm right sciatic nerve defect was created and reconstructed accordingly. Neurorege

Context. This is a case of gonadotropinoma presented with Rathke's cleft cyst. Objective. We are presenting a case of gonadotropinoma along with Rathke's cleft cyst which is unique case as being male and symptomatic gonadotropin releasing adenoma. Method. A 51 year old man was referred to our institution for evaluation of impotence and loss of libido. His endocrine screening evaluations revealed h

A 30-year-old woman presented with a cervical syrinx manifesting as hemihypesthesia. Neuroimaging found no evidence of Chiari malformation or tight cisterna magna. Serial magnetic resonance imaging studies over a 6-year period demonstrated spontaneous and complete resolution of the syrinx accompanied by an asymptomatic clinical course. The natural history of syringomyelia is highly unpredictable.

Introduction: The toxic effects of onyx, its solvent dimethyl sulphoxide (DMSO), and n-butyl 2-cyanoacrylate (NBCA) were evaluated after infusion into the subaracnoid space of a rabbit model. Methods: Each of the two various concentrations of onyx, pure DMSO, NBCA, and normal saline solution were percutaneously infused into the pontocerebellar cisternae of 39 domestic male albino rabbits, after wh

Context. The aim of this study was to explore the prognostic significance correlation between the endocrinopathy and the size of the pituitary adenoma with the sellar floor bone mineral density values using microfocus computerized tomography (μCT) analysis. Subjects and Methods. 16 consecutive patients with pituitary adenomas had full endocrinological and radiological work up prior to endoscopic t

Microbial bioelastomers prepared by the autoxidation of the unsaturated medium-long chain length copoly- 3-hydroxyalkanoate's (mlcl-PHAs) based on soybean oily acids (Sy) have been reported. Pseudomonas oleovorans were grown on a series of the mixture of octanoic acid (OA) and Sy with the weight ratio of 20:80, 28:72 and 50:50 in order to obtain unsaturated mlcl-copolyesters coded PHO-Sy-2080, PHO

We describe the synthesis and characterization of gold clusters embedded into poly (3-hydroxy octanoate-co-3-hydroxy-10-undecenoate) (PHOU), and evaluated the tissue response of the material upon implantation onto muscle tissue (rat). For this aim, PHOU was obtained by Pseudomonas oleovorans from octanoic acid (OA) and 10-undecenoic acid (UA) with a weight ratio of 50:50. The unsaturated co-polyes

Biomaterials have played an important role in the treatment of disease and the improvement of health care. Synthetic and naturally occurring biodegradable and biocompatible polymers have been used as biomaterials. Polyhydroxyalkanoates (PHAs) are promising materials for biomedical applications because they are biodegradable, non-toxic and biocompatible. We will shortly summarize the modification r

Aim: Aspiration of the abscess cavity versus excision of capsule are still in debate for the capsulated, large, superficially located abscesses. Material and Methods: Twenty patients who had large, solitary, capsulated, and superficially located lobar abscesses were analyzed retrospectively to compare the efficiency of two different surgical approaches and their impact on postoperative antibiotic

The aim of this study is to evaluate the soft tissue response of the pure and Au-embedded PPg-PEG. PP-g-PEG2000, PP-g-PEG4000, Au-PP-g-PEG2000, and AuPP-g-PEG4000 were obtained via chlorination of polypropylene and polyethylene glycol in the presence of a base with a "grafting onto" technique. Solvent cast films of these four copolymers with PP as a control group were embedded into five different

Virchow-Robin spaces (VRSs) are perivascular pia-lined extensions of the subarachnoid space around the arteries and veins as they enter the brain parenchyma. The precise etiology of these enlarged perivascular spaces (PVSs) is unknown. VRSs usually do not cause significant mass effect and neurologic deterioration. However; cystic enlargement of giant VR spaces may be misinterpreted in radiological

Biocompatibility studies of the autoxidized and unoxidized unsaturated medium-long chain length (m-lcl) co-poly-3-hydroxyalkanoates (m-lclPHAs) derived from soya oily acids have been reported. Pseudomonas oleovorans was grown on a series of mixtures of octanoic acid (OA) and soya oily acids (Sy) with weight ratios of 20:80, 28:72 and 50:50 in order to obtain unsaturated m-lcl copolyesters coded PH

Introduction: Occipital condyle fractures (OCFs) can occasionally be complicated with lower cranial nerve palsies. Discussion: Isolated 9th and 10th cranial nerve palsies following OCF are very rare. To our knowledge, we report the first case of an early onset of 9th and 10th cranial nerve palsies with an early full recovery in short period of time and discuss the probable mechanism of isolated ne

OBJECTIVE: Aneurysms originating from perforating branches of the middle cerebral artery are quite rare. Most of them arise from the lenticulostriate arteries, frequently located within the basal ganglia. We report a perforating artery aneurysm that was entirely embedded within the limen insulae. CLINICAL PRESENTATION: A 41-year-old man presented with an insular hematoma without subarachnoid hemor

Pravastatin has neuroprotective effects against aging but its role in brain injury remains unclear. This study evaluated the effects of pravastatin on the ultrastructural changes and hemorheological parameters in rats after traumatic brain injury (TBI) of right parietal cortical contusion by a controlled weight-dropping method. There were three groups: (I) Sham operated group; (II) TBI + vehicle (

Land cover and land management changes (LCLMCs) have a substantial impact on the global carbon budget and, consequently, on global climate via the biogeochemical (BGC) effects. The commonly considered BGC effects refer to the direct influence of LCLMCs on local carbon stocks (local BGC effects). However, LCLMCs also influence climate by altering the local surface energy balance due to changes in l

This study utilizes advanced 3D imaging techniques, combining X-ray and neutron tomography, to investigate the hydromechanical evolution of Idaho Gray sandstone during coupled triaxial permeability tests. The analysis involved correlating mechanical and hydraulic bulk measurements, porosity fields, strain fields derived from Digital Volume Correlation analysis and fluid speed fields derived from t