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Efficient methods for the synthesis of C2-symmetric dimers of salinomycin joined at either the C1 or C20 positions are reported. Similarly to the native structure, the C20-O-terephthalate dimer displayed activity in the low μM range against a series of cancer cell lines, while dimers joined at the C1 position were essentially inactive.

We revisit the classical problem of when a given function, which is analytic in the upper half plane ℂ+, can be written as the Fourier transform of a function or distribution with support on a half axis (-∞, b], b∈ℝ.We derive slight improvements of the classical Paley-Wiener-Schwartz Theorem, as well as softer conditions for verifying membership in classical function spaces such as Hp(ℂ+).

Off-line programmering, nya användningsområden och ökade krav på utbytbarhet har resulterat till ett ökat intresse för en förbättring av industrirobotarnas absoluta noggrannhet. En förutsättning för att detta kan ske är att industriellt anpassade mät- och kalibreringsmetoder finns tillgängliga. Målet med projektet har varit att utveckla, prova och jämföra industrianpassade robotkalibreringsmetoder

This papers describe the Open Source Officer role and the experiences from introducing this role in several companies. We outline the role description, main responsibilities, and interfaces to other roles and organizations. We investigated the role in several organization and bring interesting discrepancies and overlaps of how companies operate with OSS.

The evolutionary relationship between signals and animal senses has broad significance, with potential consequences for speciation, and for the efficacy and honesty of biological communication. Here we outline current understanding of the diversity of colour vision in two contrasting groups: the phylogenetically conservative birds, and the more variable butterflies. Evidence for coevolution of col

This paper describes the algorithms for the reconstruction and identification of electrons in the central region of the ATLAS detector at the Large Hadron Collider (LHC). These algorithms were used for all ATLAS results with electrons in the final state that are based on the 2012 pp collision data produced by the LHC at s = 8 TeV. The efficiency of these algorithms, together with the charge miside

Measurements of top quark spin observables in tt¯ events are presented based on 20.2 fb−1 of s=8 TeV proton-proton collisions recorded with the ATLAS detector at the LHC. The analysis is performed in the dilepton final state, characterised by the presence of two isolated leptons (electrons or muons). There are 15 observables, each sensitive to a different coefficient of the spin density matrix of

Type 2 diabetes (T2D) is characterized by insulin resistance and impaired insulin secretion, but the mechanisms underlying insulin secretion failure are not completely understood. Here, we show that a set of co-expressed genes, which is enriched for genes with islet-selective open chromatin, is associated with T2D. These genes are perturbed in T2D and have a similar expression pattern to that of d

Bmi1 was originally identified as a gene that contributes to the development of mouse lymphoma by inhibiting MYC-induced apoptosis through repression of Ink4a and Arf. It codes for the Polycomb group protein BMI-1 and acts primarily as a transcriptional repressor via chromatin modifications. Although it binds to a large number of genomic regions, the direct BMI-1 target genes described so far do n

Pancreatic endocrine cell differentiation depends on transcription factors that also contribute in adult insulin and glucagon gene expression. Islet cell development was examined in mice lacking MafB, a transcription factor expressed in immature alpha (glucagon(+)) and beta (insulin(+)) cells and capable of activating insulin and glucagon expression in vitro. We observed that MafB(-/-) embryos had

We present measurements of long-range angular correlations and the transverse momentum dependence of elliptic flow v2 in high-multiplicity p+Au collisions at sNN=200 GeV. A comparison of these results to previous measurements in high-multiplicity d+Au and He3+Au collisions demonstrates a relation between v2 and the initial collision eccentricity 2, suggesting that the observed momentum-space azimu