BACKGROUND: Plasma biomarkers associated with Alzheimer's disease could improve prognostic assessment for people with Down syndrome in both clinical practice and research settings. We aimed to identify the plasma biomarkers that most accurately predict longitudinal changes in Alzheimer's disease-related pathology and cognitive functioning in individuals with Down syndrome.METHODS: This longitudina

BACKGROUND: Melanoma, the deadliest form of skin cancer, exhibits resistance to conventional therapies, particularly in advanced and metastatic stages. Mitochondrial pathways, including oxidative phosphorylation and mitochondrial translation, have emerged as critical drivers of melanoma progression and therapy resistance. This study investigates the mitochondrial proteome in melanoma to uncover no

We examine how the earlier introduction of compulsory school grades affects the likelihood of receiving a mental disorder diagnosis among Swedish adolescents. We exploit a school reform that shifted the introduction of grades from grade 8 to grade 6, resulting in first exposure to grading at different ages between cohorts. Our results show that girls exposed to earlier grading are more likely to b

INTRODUCTION: Apathy and affective neuropsychiatric symptoms (NPS) are prevalent in Alzheimer's disease (AD), yet their neurobiological cause is still unclear. We examined associations between plasma neurofilament light chain (NfL) and tau pathology (p-tau181) with apathy and affective symptoms in mild cognitive impairment (MCI) and AD dementia. METHODS: This longitudinal study analyzed data from

Background: Vasovagal syncope (VVS) is a common yet challenging condition with limited effective treatments. Elastic compression stockings (ECS) have been proposed as a potential therapy, but their real-world effectiveness remains unclear. Objectives: This study sought to compare the effectiveness of lower extremity compression with thigh-high ECS vs sham stockings for the prevention of VVS recurr

This article summarises the current understanding of the heterogeneity of type 1 diabetes from a June 2024 international Expert Forum organised by the editors of Diabetes, Diabetes Care, and Diabetologia. The Forum reviewed key factors contributing to the development and progression of type 1 diabetes and outlined specific, high-priority research questions. Knowledge gaps were identified and, nota

I artikeln analyseras förfarandereglerna i den svenska tilläggsskattelagstiftningen och deras förenlighet med unionsrätten och Europakonventionen. Fokus ligger på aspekter kopplade till rapportering, sanktionsavgifter och potentiellt oskäliga skatteuttag. Särskild uppmärksamhet ägnas åt frågan om den förenklade tilläggsskatterapportens rättsliga status, risken för dubbelbestraffning i strid med ne

Purpose: The study explores how organizational space and situational strength influence bystanders’ intentions to intervene in workplace bullying within the healthcare sector. Design/methodology/approach: The research employs vignette-based interviews with 24 healthcare professionals from various medical fields in Sweden. The vignettes depict different bullying scenarios occurring in various spati

This thesis explores the conditions and factors necessary for achieving sustainability and generating long term effects from collaborative projects in the public sector. Accordingly, this paper will examine a pilot crime prevention project in Lund municipality and investigate its conditions and resources to attain sustainable organizational structures. The paper is conducted in collaboration with

Uncertainty has long been discussed in social work as an inherent element of professional practice. The present paper extends this discussion into the realm of digital social work. It reports a study of anonymous text-based online counselling provided by the social services in Sweden. We explore what kind of uncertainty is evoked when social workers respond to anonymous users through online platfo

This article presents a comprehensive database featuring the digitized, cleaned, geocoded, and linked data of the Swedish manufacturing censuses between 1863 and 1900. The data covers close to the universe of Swedish manufacturing activity and includes establishment-level information on workers, the sum of production value, and toll as output value. The article describes how the data was originall