Compartmental exchange between cells through extracellular vesicles (EVs), including exosomes and microvesicles, has emerged as a central mechanism that coordinates the complex communication between malignant and stromal cells during tumor initiation and evolution. Some of the most critical processes of EV-mediated communication, including EV biogenesis and EV uptake, can be mediated by heparan su

Cryogels have been demonstrated to be efficient when applied for protein isolation. Owing to their macroporous structure, cryogels can also be used for treating particle-containing material, e.g. cell homogenates. Another challenging development in protein purification technology is the use of molecularly imprinted polymers (MIPs). These MIPs are robust and can be used repeatedly. The paper presen

This article examines the potential of digital welfare policies and practices to enhance the wellbeing of children in China, and the congruencies and contradictions of such policies with sustainable welfare. Can child welfare be supported digitally in ways that are not environmentally destructive? The rapidly diffusing concepts of digital welfare and sustainable welfare are presented, emphasising

This article offers a novel take on the problem of judicial independence in nondemocracies. Some scholars hold that political fragmentation leads to more judicial independence; others argue that it leads to less independence in nondemocracies. These studies have focused on judicial politicization and neglected judicial corruption. Using a process-tracing controlled comparison of reforms in Georgia

The cause of brachioradial pruritus (a localized itching on the arms or shoulders) is controversial. The role of sun and cervical spine disease has been discussed. This is a report on four sisters suffering from brachioradial pruritus recurring every summer. The sisters spent much time outdoors and exposed themselves extensively to the sun. They also had occupations requiring heavy lifting. Cervic

There is increasing evidence of an interaction between the nervous and the immune systems. The aim of this study was to investigate the rôle of calcitonin gene-related peptide (CGRP) in the modulation of the elicitation of immediate and delayed, immunological and non-immunological reactions in human skin. CGRP (13 pmol and 39 pmol), and the CGRP-antagonist, CGRP/8-37/, (50 pmol and 500 pmol) were

Negative ions homologous to N- are interesting systems, since there are several bound terms within the ground configuration. The forbidden transitions between them, often dominated by the magnetic dipole contributions, are affected by term mixing - a relativistic effect. When increasing the nuclear charge in the homologous sequence of negative ions, this effect increases. In this paper we use syst

Complications of diabetes include sensory and autonomic neuropathy. The aim of the present paper was to study the degree of sensory and autonomic neuropathy and correlate these findings with the distribution and density of neuropeptidergic nerve fibers in the skin of the forearm of diabetic patients and healthy controls. We investigated 30 diabetics (24 type 1 and 6 type 2) and compared them with

A 55-year-old woman developed an airborne dermatitis on her face. Patch testing was performed and showed positive reactions to formaldehyde, thiuram mix, carba mix, and nickel sulphate. She operated a machine at work in which polyacetal granules were heated. The presence of formaldehyde in the pyrolysis smoke from the polymer was confirmed by chemical analysis.

The upper Middle to basal Upper Ordovician succession (Darriwilian to Sandbian) of the Fågelsång-3 drill core provides new important information on the graptolite biostratigraphy of Scania, southern Sweden. The Scanian succession is known largely from drill cores and a few scattered outcrops exposing only parts of the interval. The Darriwilian Almelund Shale Formation overlies the Komstad Limeston

Two men employed as painters and paperhangers showed a long-standing contact dermatitis of the hands and nummular eczema of the arms and legs. Patch testing using the standard series yielded a positive reaction to Kathon CG. Concomitant contact allergy to 1,2-benzisothiazolin-3-one was found in both patients. The occurrence of 1,2-benzisothiazolin-3-one was not declared on all of the paints to whi

Junior partners in a coalition government are torn between an eagerness to profile themselves, and to show loyalty to the coalition. We investigate when, how and why junior coalition parties affect foreign policy and profile themselves despite demands for national unity. We study two Swedish centre-right governments in 2006–2010 and 2010–2014. The parties' foreign policy positions in election mani

Substance P (SP), neurokinin A (NKA) and calcitonin gene-related peptide (CGRP) coexist in nerve fibres in the skin. CGRP causes erythema upon intracutaneous injection. The erythema is independent of axon reflexes and release of mast cell histamine. SP is known to produce a flare reaction that is dependent on axon reflexes and release of mast cell histamine. The flare reaction to NKA is known to d

Proteins of the serpin family (serine protease inhibitor) control key steps in the inflammatory, coagulation and complement systems. C1‐inhibitor deficiency predisposes to hereditary angioneurotic oedema, and other serpins control proteolytic enzymes that may cause complement activation or the forming of oedema. We investigated whether deficiency of proteins of the serpin family may predispose to

Det var en begivenhedsrig uge, den Hollandske musikfestival November Music i år faldt sammen med. Trump havde netop vundet det amerikanske præsidentvalg, og verden viste sig at være andet end det mange af os troede, den var, da vi gik i seng den skæbnesvangre tirsdag aften. Begivenheden satte sig i min krop, som en oplevelse af, at den verden jeg kendte på overraskende vis nu var ved at gå i opløs