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Pulmonary arterial hypertension is a complex and heterogeneous condition, associated with a considerable diagnostic delay, diminished exercise capacity, and poor outcomes. In pulmonary arterial hypertension, biomarker research has become a subject of intense inquiry, and novel circulating biomarkers acknowledged in a multitude of mechanistic pathways are emerging. Beyond the widely used natriureti

BackgroundInflammation and tyrosine-kinases are known mediators in the pathobiology of cardiovascular disease. Plasma biomarkers reflecting these systems may provide a noninvasive complement reflecting hemodynamics, aiding in clinical decision-making. We therefore aimed to investigate the plasma levels of vascular and inflammatory proteins, and their associations with invasive hemodynamics in adva

The purpose of this study is to look into patronage effects of extended supply outside peak hours on regional public transport services. Previous studies have shown that the service frequency is an attribute of great importance for regional passengers, but little is known about the details regarding peak and off-peak frequencies or service hours. The present study addresses this knowledge gap, dep

Based on fieldwork in a sensory science laboratory in Sweden, this paper brings the social aspects of conducting an analytical sensory panel together with consumers’ understandings of the everyday consumption context and existing practices. As part of an interdisciplinary project investigating seaweed as a new food in a Swedish context, this paper explores how seaweed as a new resource is made edi

The global shift to a knowledge-based economy is driven by rapid advancements in information and communication technology (ICT). Within this landscape, digital transformation of supply chains is crucial for enterprises, particularly small and medium-sized businesses (SMEs), seeking to boost performance and efficiency in competitive markets. Despite increased awareness of this importance, there is

The surging demand for Intelligent Transportation Systems (ITS) to deliver advanced train-related Information for dispatchers and passengers has spurred the development of advanced train delay prediction models. Despite considerable efforts devoted to developing methodologies that can be used to model train operation conditions and produce anticipated train delays, the evaluation strategies for tr

This study reports contact pressure-sliding speed maps for friction, wear and particle emissions from high-speed train brakes. Two particle spectrometers measured the airborne wear particles generated with a pin-on-disc tribometer. Particles were characterized with transmission electron microscopy and energy dispersive X-ray fluorescence. The results indicate that both the friction and wear of bra

In 2022 the Serbian Orthodox Church managed to seal off two of its longstanding ecclesial conflicts in former Yugoslavia and put an end to open hostility. The end of the conflicts seems to have been prompted as a response to the War in Ukraine. This chapter explores the Orthodox diplomacy in Montenegro and Macedonia and how it relates to the geopolitical and ecclesial role of the Serbian Orthodox

The basement membrane (BM) is a specialized layer of extracellular matrix components that plays a central role in maintaining lung and kidney functions. Although the composition of the BM is usually tissue specific, the lung and the kidney preferentially use similar BM components. Unsurprisingly, diseases with BM defects often have severe pulmonary or renal manifestations, sometimes both. Excessiv

The extracellular matrix (ECM) increasingly emerges as an active driver in several diseases, including idiopathic pulmonary arterial hypertension (IPAH). The basement membrane (BM) is a specialized class of ECM proteins. In pulmonary arteries, the BM is in close contact and direct proximity to vascular cells, including endothelial cells. So far, the role of the BM has remained underinvestigated in

Rationale: Pulmonary hypertension (PH) is a common, severe comorbidity in interstitial lung diseases such as pulmonary fibrosis (PF), and it has limited treatment options. Excessive vascular fibrosis and inflammation are often present in PH, but the underlying mechanisms are still not well understood. Objectives: To identify a novel functional link between natural killer T (NKT) cell activation an

Copepods may contribute to harmful algal bloom formation by selectively rejecting harmful cells. Additionally, copepods and the chemical cues they exude, copepodamides, have been shown to induce increased toxin production in paralytic and amnesic toxin producing microalgae. However, it is unknown if diarrhetic shellfish toxin (DST) producers such as Dinophysis respond to copepods or copepodamides

Metal matrix composites (MMCs) possess excellent material properties due to the combination of metals and reinforcing phases, yet this reduces their machinability. Numerous studies have shown that, due to the ploughing effect of the cutting tool, the edge effect can directly impact the material removal mechanism and the generation of surface integrity. However, the influence of different cutting-e

BACKGROUND: The diagnostic role of signal-averaged ECG (SAECG) in arrhythmogenic right ventricular cardiomyopathy (ARVC) has lately been questioned. We assessed the value of SAECG-derived late ventricular potentials (LP) in ARVC diagnosis and its association with disease manifestations.METHODS AND RESULTS: Patients with definite ARVC diagnosis or genotype-positive family members who underwent SAEC

This paper connects insights from the literature on cosmopolitan worldviews and the effects of perspective-taking in political science, (intergroup) anxiety in social psychology, and identity economics in a vignette-style experiment. In particular, we asked German respondents about their attitudes towards a Syrian refugee, randomizing components of his description (N = 662). The main treatment des