Aims: Drug development for paediatric pulmonary arterial hypertension (PAH) ispressingly needed. Experts from the US Food and Drug Administration, EuropeanMedicines Agency, Health Canada, key opinion leaders, academia, patients, and industry representatives held a workshop on 12th June 2017 dedicated to addressing challenges and unmet needs. This report summarises the approaches proposed during th

Denne artikel undersøger to typer af litterære karakterer, som skabes i Rushy Rashids Et løft af sløret (2000), Özlem Cekic’ Fra Føtex til Folketinget (2009) og Geeti Amiris Glansbilleder (2016). Den første type er den muslimske kvinde som forbillede for kvindekamp, og den anden er patriarken som produceret af, hvad muslimske debattører har kaldt “rygtesamfundet”. Forfatterne fremstiller den såkal

In their comment piece, Laycock and Lam (Environ. Res. Lett. 13 068001) focused on the importance for reducing emissions of actions beyond individual choices and overconsumption, and raise the issue of family planning as a human right. Here we respond that both individual and collective actions, in private and professional life, are important to reducing emissions to near zero in the next few deca

While it is understood that cities generate the majority of carbon emissions, for most cities, towns, and rural areas around the world no carbon footprint (CF) has been estimated. The Gridded Global Model of City Footprints (GGMCF) presented here downscales national CFs into a 250 m gridded model using data on population, purchasing power, and existing subnational CF studies from the US, China, EU

Semiconductor nanowires have properties that make them potentially useful for applications in future electronic, photovoltaic, and optoelectronic devices. A powerful nanowire fabrication technique is the use of a nanoparticle as a preferential nucleation site, from which a nanowire grows. There has been significant progress in nanowire growth assisted by Au nanoparticles over the past 20 years. Ho

Aims: Most benign bladder pathologies are associated with an increase of extracellular matrix (ECM—fibrosis) and may progress from formation of stiffer matrix to a more compliant structure. The aims were to summarize current knowledge of the origins of bladder fibrosis and consequences in bladder function. Methods: A meeting at the International Consultation on Incontinence Research Society 2017 c

Pro-inflammatory and amyloidogenic S100A9 protein is an important contributor to Alzheimer’s disease (AD) pathology. Traumatic brain injury (TBI) is viewed as a precursor state for AD. Here we have shown that S100A9-driven amyloid-neuroinflammatory cascade was initiated in TBI and may serve as a mechanistic link between TBI and AD. By analyzing the TBI and AD human brain tissues, we demonstrated t

Abstract in Undetermined Under närmare ett decennium har jag följt behandlingen av AstraZenecas numera fastslagna överträdelser av konkurrensrätten. Den fällande domen är kanske inte alldeles oväntad, även om det funnits anledning att diskutera olika frågeställningar. När jag ser tillbaka på de samlade bidragen slår det mig att min främsta invändning är att myndigheterna så enögt främjar den gener

This paper uses logbook data from Swedish Baltic Sea cod trawlers to investigate the revenue target hypothesis. Incomes from fishing can be highly variable and difficult to predict and it is possible that fishermen set specific revenue targets for their fishing trips to simplify decision making. In this paper a discrete choice stopping model is used where the fishermen must decide to stop or conti

The aim of this paper is to combine remote sensing data with geo-coded household survey data in order to measure the impact of different socio-economic and biophysical factors on maize yields. We use multilevel linear regression to model village mean maize yield per year as a function of NDVI, commercialization, pluriactivity and distance to market. We draw on seven years of panel data on African

Fishing access agreements have been widely criticized but there is little quantitative evidence of their effects on the economies of developing countries. The aim of this paper is to investigate the influence of the European Union’s fishing access agreements on 15 African countries’ fish exports to the OECD. More specifically, we investigate the effects on the extensive and intensive margins of tr

The NDVI is a remotely sensed vegetation index that is frequently used in ecological studies. There is, however, a lack of studies that evaluate the ability of the NDVI to detect fine-scale variation in grassland plant community composition and species richness. Ellenberg indicators characterize the environmental preferences of plant species—and community-mean Ellenberg values have been used to ex

The shaping of a city and its future relates to official decisions made in city planning meetings, where daily planning matters and decision-making processes adapt to changing societal circumstances. The interest of this research lies in how planning is officially established, managed and practiced in the setting of a Jordanian city, and its local districts. This interest leads the research to obs

Laurie Cohen and Joanne Duberley describe their use of an unconventional data source-a radio programme-to study celebrity careers. This source also includes music, which evokes memories, and elicits emotions not readily captured in conventional interviews. They used the archives of the BBC Radio 4 programme Desert Island Discs to study the careers of well-known research scientists. The programme's

The presence of contralateral tactile input can profoundly affect ipsilateral tactile perception, and unilateral stroke in somatosensory areas can result in bilateral tactile deficits, suggesting that bilateral tactile integration is an important part of brain function. Although previous studies have shown that bilateral tactile inputs exist and that there are neural interactions between inputs fr