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Identification of a single molecular trait that is determinant of common malignancies may serve as a powerful diagnostic supplement to cancer type-specific markers. Here, we report a DNA methylation mark that is characteristic of seven studied malignancies, namely cancers of lung, breast, prostate, pancreas, colorectum, glioblastoma and B cell chronic lymphocytic leukaemia (CLL) (n = 137). This ma

Introduction: Dysfunction of immunoglobulins (Igs) has been detected in association with antiepileptic drugs (AEDs) and in newly diagnosed epilepsy patients. The aim of this study was to evaluate the effect of clinical features and the current or past use of AEDs on serum Ig concentrations in a well-examined group of patients with refractory epilepsy. Patients and methods: Using a nephelometric me

DNA methylation patterns have been recognised as cancer-specific markers with high potential for clinical applications. We aimed at identifying methylation variations that differentiate between breast cancers and other breast tissue entities to establish a signature for diagnosis. Candidate genomic loci were analysed in 117 fresh-frozen breast specimens, which included cancer, benign and normal br

Background: Lead-time is defined as the time by which screening advances the diagnosis compared with absence of screening. A sufficiently long lead-time needs to be achieved so that cancer can be detected while still curable. A very short lead-time may indicate poor sensitivity of the screening test, while a very long lead-time suggests overdiagnosis. Material and methods: In the first screening r

Reflective reconfigurable intelligent surface (RIS) technology is regarded as an innovative, cost- and power-effective solution that aims at influencing the wireless channel through controlled scattering. The technology can be realized by using metamaterials and/or resonant elements that scatter electromagnetic waves with a configurable phase shift. Most of the previous work on beamforming techniq

OBJECTIVE: To identify and characterize genetic loci associated with the risk of developing anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV).METHODS: Genetic association analyses were performed after Illumina sequencing of 1,853 genes and subsequent replication with genotyping of selected SNPs in a total cohort of 1110 Scandinavian cases with granulomatosis with polyangiit

OBJECTIVES: Fatigue is common and severe in primary Sjögren's syndrome (pSS). The aim of this study was to identify genetic determinants of fatigue in pSS through a genome-wide association study.METHODS: Patients with pSS from Norway, Sweden, UK and USA with fatigue and genotype data available were included. After genotype imputation and quality control, 682 patients and 4 966 157 genetic markers

Ett viktigt mål för samhället, särskilt för utbildningssystemen, är att vi människor blirbättre på att få syn på växter och på deras betydelse i ekosystemen. Vi behöver över-vinna vad som benämns ‘växtblindhet’. I denna artikel föreslår vi att variationsteoriär en bra utgångspunkt i utbildning och utvärdering av växtidentifiering inom högreutbildning. Vi redovisar exempel från svensk universitetsu

Recently, interest has been growing in investigating rhythm cognition and behavior in nonhuman animals as a way of tracking the evolutionary origins of human musicality—that is, the ability to perceive, enjoy, and produce music. During the past 2 decades, an explosion of theoretical proposals have aimed at explaining why and how humans have evolved into musical beings, and the empirical comparativ

Short-term memory is implicated in a range of cognitive abilities and is critical for understanding primate cognitive evolution. To investigate the effects of phylogeny, ecology and sociality on short-term memory ability, we tested 421 non-human primates across 41 species in a pre-registered, experimental delayed-response task. Our results confirm previous findings that longer delays decrease memo

BACKGROUND: Major depressive disorder (MDD) is one of the most common psychiatric disorders and is a great disease burden. However, its underlying pathophysiology and aetiology remain poorly understood. Available evidence suggests that circulating microRNAs (miRNAs) are associated with MDD, but it is still unknown whether miRNAs can predict subsequent incident MDD.METHODS: In this nested case-cont

BACKGROUND AND AIMS: Mitochondrial DNA copy number (mtDNA-CN) is a surrogate biomarker of mitochondrial dysfunction and is associated with type 2 diabetes (T2D) and cardiovascular disease (CVD). However, despite being associated with both CVD and T2D, it is not known what role mtDNA-CN has in the association between T2D and CVD. Our aims were to investigate whether, (1) baseline mtDNA-CN is associ