Neuropeptide Y (NPY) exerts anxiolytic-and antidepressant-like effects in rodents that appear to be mediated via Y1 receptors. Gene therapy using recombinant viral vectors to induce overexpression of NPY in the hippocampus or amygdala has previously been shown to confer anxiolytic-like effect in rodents. The present study explored an alternative and more specific approach: overexpression of Y1 rec

This paper presents a 3rd-order, 3-bit continuous-time (CT) \Updelta\Upsigma Δ Σ modulator for an LTE radio receiver. A return-to-zero (RZ) pulse, centered in the sampling period by a quadrature clock, is used in the innermost DAC to reduce the sensitivity to loop-delay variations in the modulator, and omit implementing the additional loop delay compensation usually needed in CT modulators. The pe

Objective: Assess the cost effectiveness of budesonide/formoterol (BUD/FORM) Turbuhaler (R) +tiotropium (TIO) HandiHaler (R) vs. placebo (PBO)+TIO in patients with chronic obstructive pulmonary disease (COPD) eligible for inhaled corticosteroids/long-acting beta(2)-agonists (ICS/LABA). Methods: The cost-effectiveness analysis was based on the 12-week, randomised, double-blind CLIMB trial. The stud

Artikeln presenterar kortfattat min forskning om etiska frågor kring nutritionell genomik och dess tillämpning i personaliserad nutrition.

The photo-physics and -chemistry of indoles are known to be highly complex and strongly dependent on their precise molecular structure and environment. Combination of spectroscopic analysis with quantum chemical calculations should be a powerful tool to unravel precise excited state deactivation mechanisms. At the same time, combined studies are seldom and likely far from trivial. In this work we

The determination of the phospholipid fatty acid (PLFA) pattern of soil organisms has become one of the most commonly used methods to study microbial community structure. Here we recapitulate the background of our work applying the PLFA method to soil in the early 1990s. We also stress that although the PLFA method was, and still is, a rapid and sensitive method to detect changes in the microbial

Virtual communities and social networks assume and consume more aspects of people's lives. In these evolving social spaces, the boundaries between actual and virtual reality, between living individuals and their virtual bodies, and between private and public domains are becoming ever more blurred. As a result, users and their presentations of self, as expressed through virtual bodies, are increasi

Background: Moths rely heavily on pheromone communication for mate finding. The pheromone components of most moths are modified from the products of normal fatty acid metabolism by a set of tissue-specific enzymes. The turnip moth, Agrotis segetum uses a series of homologous fatty-alcohol acetate esters ((Z)-5-decenyl, (Z)-7-dodecenyl, and (Z)-9 tetradecenyl acetate) as its sex pheromone component

In high-energy collisions, the spatio-temporal size of the particle production region can be measured using the Bose-Einstein correlations of identical bosons at low relative momentum. The source radii are typically extracted using two-pion correlations, and characterize the system at the last stage of interaction, called kinetic freeze-out. In low-multiplicity collisions, unlike in high-multiplic

A key aspect of leadership is the followers’ constructions of its value and relevance. Based on two empirical, qualitative case studies, this paper highlights the importance of the ‘demand’ for leadership when leader–follower relationships are established. We further discuss how followers influence, inhibit and initiate managerial leadership (i.e. leadership acts from their formal superior targeti

Background: This contribution deals with chemical processes at the biological membranes of endothelial cells in blood vessels. A basic observation is that the intensity of blood flow navigates the vascular width through a negative feedback circle. When the blood flow increases, the vessels become wider; when it decreases the vascular smooth muscle cells contract. The anionic polyelectrolyte hepara

Review of Ferm, Olle & Åkestam, Mia (eds) "Härnevi kyrka och socken : perspektiv på ett uppländskt lokalsamhälle under medeltiden" (2012)

Steven Spielberg's film Saving Private Ryan is at the centre of this text, with a particular focus on how it displays the past in ways that place the audience in the middle of the historical action. By looking at various technical breakthroughs predating this film, it is argued that what we here see is the beginning of a new kind of 360-degree historiography that nowadays dominates historical epic

We discuss general non-stationary spatio-temporal surfaces that involve dynamics governed by velocity fields. The approach formalizes and expands previously used models in analysis of satellite data of significant wave heights. We start with homogeneous spatial fields. By applying an extension of the standard moving average construction we obtain models which are stationary in time. The resulting

BackgroundA common genetic variant (rs10993994) in the 5' region of the gene encoding β-microseminoprotein (MSP) is associated with circulating levels of MSP and prostate cancer risk. Whether MSP levels are predictive of prostate cancer risk has not been evaluated.MethodsWe investigated the prospective relationship between circulating plasma levels of MSP and prostate cancer risk in a nested case-

Treatment of [Fe-3(CO)(12)] with tri(2-furyl)phosphine (PFu(3)) or tri(2-thienyl)phosphine (PTh3) in dichloromethane at 40 degrees C leads to facile phosphorus carbon bond scission affording di-iron furyl- and thienyl-bridged complexes [Fe-2(CO)(6)(mu-eta(1),eta(2)-C4H3E)(mu-P(C4H3E)(2))] (1 E = O, Fu; 3 E = S, Th) in good yields, together with smaller amounts of the phosphine-substituted [Fe-2(CO

Young exocrine pancreas insufficient (EPI) pigs given a commercial feed (polymeric diet) show growth retardation that can be reversed by dietary supplementation with pancreatic enzymes. Our aim was to investigate if providing an elemental diet, mimicking a pre-digested diet, can support body growth in EPI-pigs. Thus, EPI-pigs, pancreatic duct-ligated at 12.2 +/- 2.6 weeks of age (15.3 +/- 4.8 kg),

We report the discovery of ferroelectricity below 4.5 K in highly underdoped La2CuO4+x accompanied by slow charge dynamics which develop below T similar to 40 K. An anisotropic magnetoelectric response has also been observed, indicating considerable spin-charge coupling in this lightly doped parent high-temperature copper-oxide superconductor. The ferroelectric state is proposed to develop from po