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Imaging large areas of a sample non-destructively and with high resolution is of great interest for both science and industry. For scanning coherent X-ray diffraction microscopy, i. e., ptychography, the achievable scan area at a given spatial resolution is limited by the coherent photon flux of modern X-ray sources. Multibeam X-ray ptychography can improve the scanning speed by scanning the sampl

Bacterial adhesion to the host is the most decisive step in infections. Trimeric autotransporter adhesins (TAA) are important pathogenicity factors of Gram-negative bacteria. The prototypic TAA Bartonella adhesin A (BadA) from human-pathogenic Bartonella henselae mediates bacterial adherence to endothelial cells (ECs) and extracellular matrix proteins. Here, we determined the interaction between B

I bokens kapitel diskuterar Fredrik N G Andersson och Lars Jonung finans- och penningpolitiken i Europa efter coronapandemin. Sedan euron, den gemensamma valutan, infördes den förste januari 1999 har såväl penningpolitiken som finanspolitiken varit föremål för en rad reformer. Dessa har varit påverkade av erfarenheterna och tolkningen av tidigare ekonomiska kriser. I samband med coronapandemin 202

PurposeEpithelial ovarian cancer is usually diagnosed in the advanced stages. To choose the best therapeutic approach, an accurate preoperative assessment of the tumour extent is crucial. This study aimed to determine whether the peritoneal cancer index (PCI), the amount of ascites, and the presence of cardiophrenic nodes (CPLNs) visualized by computed tomography (CT) can assess the tumour extent

This thesis describes studies regarding the design, synthesis, and analysis of new types of electro-responsive [8]annulene-based switches.A starting material for the targeted material is dibenzo[a,e]cyclooctatetraene (dbCOT). The first part of the thesis describes an improved synthesis of this structure using a copper(I) catalyzed decarboxylative approach. Using this method, dbCOT was prepared in

BACKGROUND: This individual-patient data meta-analysis investigated the effects of enhanced recovery after surgery (ERAS) protocols compared with conventional care on postoperative outcomes in patients undergoing pancreatoduodenectomy. METHODS: The Cochrane Library, MEDLINE, Embase, Scopus, and Web of Science were searched systematically for articles reporting outcomes of ERAS after pancreatoduode

HIV infection affects the course of tuberculosis (TB), and HIV and Mycobacterium tuberculosis (Mtb) synergize in disease progression through complex immunological interplay. To gain further understanding of these mechanisms, we compared the microRNA (miRNA) and small nucleolar RNA (snoRNA) expression patterns in whole blood of individuals with active TB, with and without HIV coinfection (HIV+/TB+

We highlight important assumptions associated with the research program in sustainability science developed around “corporate biosphere stewardship” and the promise of “science-business initiatives.” In doing so, we interrogate a central concept in this research, “keystone actors.” We analyze the program based on associated research outputs and communications, focusing on three key challenges 1) i

Shiga toxin-producing Escherichia coli O157:H7 is a virulent strain causing severe gastrointestinal infection, hemolytic uremic syndrome and death. To date there are no specific therapies to reduce progression of disease. Here we investigated the effect of pooled immunoglobulins (IgG) on the course of disease in a mouse model of intragastric E. coli O157:H7 inoculation. Intraperitoneal administrat

An increasing number of extremely premature infants survive the neonatal period and beyond. Little is known about the maturation of the preterm infant’s metabolome and its relation to the development of morbidities. Using 1H-NMR, we investigated the serum metabolic profile of 87 infants born at a gestational age (GA) <28 weeks [mean GA (SD) 25.4 (1.4) weeks] in samples longitudinally collected fro

Objective: This study aimed to investigate and compare the morphological and biochemical characteristics of the hippocampus and the spatial memory of young adult ApoE–/– mice on a standard chow diet, a low-fat diet (LFD), a high-fat diet (HFD), and an HFD supplemented with lingonberries. Methods: Eight-week-old ApoE–/– males were divided into five groups fed standard chow (Control), an LFD (LF), a

Just like other complex biological features, image vision (multi-pixel light sensing) did not evolve suddenly. Animal visual systems have a long prehistory of non-imaging light sensitivity. The first spatial vision was likely very crude with only few pixels, and evolved to improve orientation behaviors previously supported by single-channel directional photoreception. The origin of image vision wa

BACKGROUND: Plasma biomarkers for Alzheimer's disease (AD) have broad potential as screening tools in primary care and disease-modifying trials. Detecting elevated amyloid-β (Aβ) pathology to support trial recruitment or initiating Aβ-targeting treatments would be of critical value. In this study, we aimed to examine the robustness of plasma biomarkers to detect elevated Aβ pathology at different

Background and Objectives: Early vascular aging determines a more rapid course of age-related arterial changes. It may be induced by a proinflammatory state, caused by hyperuricemia and metabolic syndrome and their interrelationship. However, the impact of serum uric acid (SUA) on early arterial stiffening and vascular function remains uncertain. Materials and Methods: A total of 696 participants

The inclusion of family members in the acute care of older persons with complex needs results in better coordination of care and reduces the frequency and/or duration of rehospitalisation. Therefore, healthcare professionals need a tool to assess the collaboration with family members on acute hospital wards. The aims were to test the psychometric properties of the Swedish version of the Family Col

Kemisk vittring kallas processen när mineralkorn löses upp och sönderdelas i molekyler eller atomer. Det är en viktig process, bland annat för att den frigör ämnen som skyddar marken från försurning och som fungerar som näringsämnen för växter. För de så kallade baskatjonerna kalium, kalcium, magnesium och natrium är vittringen i marken bland de största källorna. Framför allt de tre förstnämnda baBase cations are important in forest soils as nutrients for vegetation and protection against soil acidification. Today, base cations have been lost from soils through acidification and forest harvesting. With low levels in soils, temporary situations of deficiency could occur. One of the largest inputs of base cations to soils is minerals weathering, which makes it an important process. It is, ho

Mental health law is inextricably connected to key human rights protected under the European Convention on Human Rights (1950, ECHR or the Convention), such as the right to freedom of liberty, to personal autonomy and physical and mental integrity, and to the right to not be discriminated against. This chapter outlines the fundamental procedural and substantive standards developed by the European

Purpose: Relapse after allogeneic hematopoietic cell transplantation (allo-HCT) remains the first cause of transplant failure in patients with Philadelphia-positive (Ph ) acute lymphoblastic leukemia (ALL). In other hematologic malignancies, therapeutic advances resulted in significant improvement over time in survival of patients relapsing after transplant. Experimental Design: We compared outcom