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DNase I hypersensitive sites (DHS) are abundant in regulatory elements, such as promoter, enhancer and transcription factor binding sites. Many studies have revealed that disease-associated variants were concentrated in DHS-related regions. However, limited studies are available on the roles of DHS-related variants in lung cancer. In this study, we performed a large-scale case-control study with 2

Objectives: The objective is to present the antibiotic elution from a locally implanted gentamicin containing hydroxyapatite and calcium sulphate bone substitute with an extended follow up of 30 days. We also compare the pharmacokinetics of the ceramic bone substitute with a published study on gentamicin containing poly (methyl methacrylate) (PMMA) bone cement used in primary total hip arthroplast

När konsumenter köper en produkt så har de förväntningar på vad produkten kommer att kunna leverera. Rationella argument försöker försäkra sig om att produktens tekniska egenskaper kommer att bli till belåtenhet. Men det är ändå ofta känslan som får sista ordet. Känns produkten rätt, tillräckligt attraktiv, eller är den ens värd att betala så mycket för? Det är väl känt att människans perception iWhen consumers buy a new product, they have expectations about what that product will deliver. The consumer’s rational reasoning may try to ascertain whether the technical performance of the product will be fulfilled. Nevertheless, the final word is often subjective. Does it feel right? Is the product attractive, is it worth paying that much for? It is well established that human perception is hig

OBJECTIVES: Deep bone and joint infections (DBJI) are directly intertwined with health, demographic change towards an elderly population, and wellbeing.The elderly human population is more prone to acquire infections, and the consequences such as pain, reduced quality of life, morbidity, absence from work and premature retirement due to disability place significant burdens on already strained heal

This study investigated bone regeneration in the femoral neck canal of osteoporotic rats using a novel animal model. A calcium sulphate (CS)/hydroxyapatite (HA) carrier was used to deliver a bisphosphonate, zoledronic acid (ZA), locally, with or without added recombinant human bone morphogenic protein-2 (rhBMP-2). Twenty-eight-week-old ovariectomized Sprague-Dawley rats were used. A 1 mm diameter

The neutron-rich isotopes 211,213Tl, beyond the N=126 shell closure, have been studied for the first time in isomer γ-ray decay, exploiting the fragmentation of a primary uranium beam at the Fragment Separator-Rare Isotopes Investigation at GSI setup. The observed isomeric states in 211,213Tl show a deviation from the seniority-like scheme of 209Tl. The possible interpretation of the data is discu

I jordbrukslandskapet produceras en mängd ekosystemtjänster, där mat, foder och fiber kanske är de mest uppenbara. För att dessa försörjande tjänster skall kunna produceras på ett långsiktigt hållbart sätt krävs även en rad så kallade intermediära ekosystemtjänster, som kretslopp av näringsämnen, pollinering, naturlig kontroll av skadeinsekter och reglering av vattenflöden. Även om dessa ekosystem

We present measurements of azimuthal correlations of charged hadron pairs in sNN=200 GeV Au+Au collisions for the trigger and associated particle transverse-momentum ranges of 14GeV/c) correlations is suppressed compared with that of correlations measured in p+p collisions. At the lowest associated particle pT(0.5

Multifunktionella landskap producerar mat, fiber och bränsle, samt en mängd andra ekosystemtjänster såsom biologisk mångfald, rekreation, ren luft och rent vatten. I SAPES och associerade forskningsprojekt har vi arbetat med att förstå hur olika jordbruksmetoder och landskapets struktur påverkar biologisk mångfald och ekosystemtjänster som beror av dessa. Vi har testat påverkan på arter och ekosys

Event-based sampling provides a way of lowering the resource utilization in sensing and communication applications. By sending a sample only when some triggering condition is fulfilled, we can ensure that the transmitted samples actually carry innovation. However, in an event-based system, the state estimation problem becomes complicated, as the information of not receiving a measurement must be t

Objective: Diagnosis of frontotemporal dementia (FTD) is complicated by the overlap of clinical symptoms with other dementia disorders. Development of robust fluid biomarkers is critical to improve the diagnostic work-up of FTD. Methods: CSF concentrations of placental growth factor (PlGF) were measured in the discovery cohort including patients with FTD (n = 27), Alzheimer disease (AD) dementia (