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Little is known about the hemodynamic response to exercise in heart failure patients at various ages before and after heart transplantation (HT). This information is important because postoperative hemodynamics may be a predictor of survival. To investigate the hemodynamic response to HT and exercise, we grouped our patients based on preoperative age and examined their hemodynamics at rest and dur

Background: In the present study the effect of a workplace-oriented intervention for persons on long-term sick leave for clinical burnout, aimed at facilitating return to work (RTW) by job-person match through patient-supervisor communication, was evaluated. We hypothesised that the intervention group would show a more successful RTW than a control group. Methods: In a prospective controlled study

Molecular LiCl and Li2Cl2 have been studied in the vapor phase with valence photoelectron and photoelectron-photoion coincidence spectroscopies. These two techniques determine the binding energies in fundamentally different ways. Binding energies obtained from photoelectron spectra are usually taken as the vertical ionization energies of the corresponding electronic states. In cases with several o

sing an integrative approach in which genetic variation, gene expression, and clinical phenotypes are assessed in relevant tissues may help functionally characterize the contribution of genetics to disease susceptibility. We sought to identify genetic variation influencing skeletal muscle gene expression (expression quantitative trait loci [eQTLs]) as well as expression associated with measures of

Background: Autism spectrum disorders (ASD) are severe neurodevelopmental disorders with the male:female ratio of 4:1, implying the contribution of X chromosome genetic factors to the susceptibility of ASD. The ribosomal protein L10 (RPL10) gene, located on chromosome Xq28, codes for a key protein in assembling large ribosomal subunit and protein synthesis. Two non-synonymous mutations of RPL10,

Throughout the last decade, there has been an increased interest in various forms of dynamic epistemic logics to model the flow of information and the effect this flow has on knowledge in multi-agent systems. This enterprise, however, has mostly been applicationally and semantically driven. This results in a limited amount of proof theory for dynamic epistemic logics. In this paper, we try to com

Evaluation of Specific Absorption Rate (SAR) for multiple antenna systems is becoming important, with the upcoming deployment of LTE-Advanced. In this work, the influence of different antenna locations and antenna types was investigated for stand-alone SAR and simultaneous SAR, to provide some guidelines for antenna design in multi-antenna handsets. For simultaneous SAR, different phase shifts bet

Migratory movements in air or water are strongly affected by wind and ocean currents and an animal which does not compensate for lateral flow will be drifted from its intended direction of movement. We investigated whether arctic shorebirds during autumn migration in the region of South Sweden and the southern Baltic Sea compensate for wind drift or allow themselves to be drifted when approaching

Human group IIA-secreted phospholipase A(2) (sPLA(2)-IIA) is a bactericidal molecule important for the innate immune defense against Gram-positive bacteria. In this study, we analyzed its role in the host defense against Streptococcus pyogenes, a major human pathogen, and demonstrated that this bacterium has evolved a previously unidentified mechanism to resist killing by sPLA(2)-IIA. Analysis of

This anthology, written in English and German, is a report from the symposium "Richard Wagner - Werk und Wirkungen / His Works and their Impact" held in Stockholm, 27-29 January, 2013, arranged by the Royal Swedish Academy of Letters, History and Antiquities, together with the Royal Swedish Academy of Music, the Royal Swedish Opera, and the University College of Opera in Stockholm. The authors off

1. Aquatic ecosystems in Northern Europe are expected to face increases in temperature and water colour (TB) in future. While effects of these factors have been studied separately, it is unknown whether and how a combination of them might affect phenological events and trophic interactions. 2. In a mesocosm study, we combined both factors to create conditions expected to arise during the coming ce

Abstract is not available

Through enhancement of 6-mercaptopurine (6MP) bioavailability and inhibition of purine de novo synthesis, high-dose methotrexate (HD-MTX) may increase incorporation into DNA of 6-thioguanine nucleotides, the cytotoxic metabolites of 6MP. Patients with intermediate activity of thiopurine methyltransferase (TPMTIA) have higher cytosol 6-thioguanine nucleotide levels. We investigated toxicity followi

To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, overwhelmingly of European descent. We identified ten previously unreported T2D susceptibility loci, including two showing sex-differentiated association. Genomewide analyses of these data