The ends of eukaryotic chromosomes are protected by specialized telomere chromatin structures. Rap1 and Cdc13 are essential for the formation of functional telomere chromatin in budding yeast by binding to the double-stranded part and the single-stranded 3' overhang, respectively. We analyzed the binding properties of Saccharomyces castellii Rap1 and Cdc13 to partially single-stranded oligonucleot

Purpose: The purpose of this paper is to provide an understanding of value co-creation in services as a multidimensional political construct that takes place across different “regimes of value” (Appadurai 1986). Design/Methodology/Approach: A case study of waste management services in Sweden serves as an illustration of how this construct takes place. Findings: There is a strategic potential for s

This study explores patients' knowledge of cardiac risk factors (CRFs), analyses how information and advice about CRFs are documented in clinical practice, and assesses patient adherence to received instructions to decrease CRFs. Systemic lupus erythematosus (SLE) patients with >= 4 ACR criteria participated through completing a validated cardiovascular health questionnaire (CHQ). Kappa statistics

Women with Lynch syndrome (LS) have up to a 60% lifetime risk of endometrial cancer (EC) and up to a 24% risk of ovarian cancer (OC). Gynecological surveillance is recommended, but the benefit and how it should be performed remain unclear. The purpose of this study was to assess diagnostic modalities for gynecological screening of LS patients in Sweden and clinical outcome.

The de Branges spaces of entire functions generalize the classical Paley-Wiener space of square summable bandlimited functions. Specifically, the square norm is computed on the real line with respect to weights given by the values of certain entire functions. For the Paley-Wiener space, this can be chosen to be an exponential function where the phase increases linearly. As our main result, we esta

α-Synuclein (α-syn) is a protein prevalent in neural tissue and known to undergo axonal transport. Intracellular α-syn aggregates are a hallmark of Parkinson's disease (PD). Braak and collaborators have suggested that in people who are destined to eventually develop PD, α-syn aggregate pathology progresses following a stereotypic pattern, starting in the olfactory bulb (OB) and the gut. α-Synuclei

Mesoamerican nephropathy is an epidemic of chronic kidney disease (CKD) unrelated to traditional causes, mostly observed in sugarcane workers. We analysed CKD mortality in Costa Rica to explore when and where the epidemic emerged, sex and age patterns, and relationship with altitude, climate and sugarcane production.

A qualitative analysis on capacitance-voltage and conductance data for high-kappa/InAs capacitors is presented. Our measured data were evaluated with a full equivalent circuit model, including both majority and minority carriers, as well as interface and border traps, formulated for narrow band gap metal-oxide-semiconductor capacitors. By careful determination of interface trap densities, distribu

Fine-needle aspiration (FNA) features of elastofibroma dorsi (EFD) in a 56-year-old woman were evaluated. The patient presented with 5 cm soft tissue mass located between the inferior part of scapula and the chest wall. FNA smears were hypercellular, characterized by a mixture of uniform spindle cells, mature adipocytes, and collagen tissue fragments in varying proportions. The cytological finding

There is a need for analytical methods capable of monitoring blood antibiotic levels in real time. Here we present a method for quantifying antibiotic levels in whole blood that does not require any sample pretreatment. The tests employ the enzyme penicillinase to assay for penicillin G, penicillin V and ampicillin using a flow-injected biosensor, the Enzyme Thermistor. Optimal flow rates, sample

This paper is an investigation in the use of truthmaker theory for exploring the relation of logic to world, and as a tool for metaphysics. A variant of truthmaker theory, which we call the simple theory, is defined and defended against objections. It is characterized formally, and its central features are derived. As part of this project, we give a formal metaphysics based on nondeterministic nec

Abstract in UndeterminedThe stabilization characteristics and local extinction structures of partially premixed methane/air flames were studied using simultaneous OH-PLIF/PIV techniques, and large eddy simulations employing a two-scalar flamelet model. Partial premixing was made in a mixing chamber comprised of two concentric tubes, where the degree of partial premixing of fuel and air was control

The middle Darriwilian delta C-13 excursion (MDICE), one of the least known of the Ordovician delta C-13 excursions, has previously been recorded only from the Middle Ordovician of Baltoscandia. Analysis of many recently collected limestone samples from the Guniutan Formation at two Yangtze Platform localities show elevated delta C-13 values in the same biostratigraphic interval (Microzarkodina oz

Osteoporosis-related fractures constitute a major health concern not only in women but also in men. Insulin-like growth factor 1 (IGF-1) is a key determinant of bone mass, but the association between serum IGF-1 and incident fractures in men remains unclear. To determine the predictive value of serum IGF-1 for fracture risk in men, older men (n = 2902, mean age of 75 years) participating in the pr

Four different thermal manikins (male and female shapes)in three different laboratories (UK, Sweden, and China) were used to determine the clothing thermal insulation values of 52 non-Western, mainly indoor clothing ensembles in order to expand the existing clothing database for use with ANSI/ASHRAE Standard 55-2013, Thermal Environmental Conditions for Human Occupancy (ASHRAE 2013a), ISO Standard

A long term experiment was conducted in a primary forest area in Amazonia, with continuous in-situ measurements of aerosol optical properties between February 2008 and April 2011, comprising, to our knowledge, the longest database ever in the Amazon Basin. Two major classes of aerosol particles, with significantly different optical properties were identified: coarse mode predominant biogenic aeros

We have analyzed an almost 14,000 year old peat sequence on the island of Isla de los Estados (55 degrees S. 64 degrees W), east of Tierra del Fuego, in the core of the Southern Hemisphere Westerlies. A multitude of methods have been used: high resolution C-14 dating; detailed lithologic descriptions including humification degree; loss on ignition; magnetic susceptibility; bulk density; pollen and